| Wu Fang,Fang Yeying,Hu Kai,Zhang Yong,Wang Rensheng.Prognostic value of iASPP for nasopharyngeal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2017,37(4):273-277 |
| Prognostic value of iASPP for nasopharyngeal carcinoma |
| Received:December 07, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.04.007 |
| KeyWords:iASPP Nasopharyngeal carcinoma Prognosis |
| FundProject:国家自然科学基金（81472807） |
| Author Name | Affiliation | E-mail | | Wu Fang | Department of Radiation Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China | | | Fang Yeying | Department of Radiation Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China | | | Hu Kai | Department of Radiation Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China | | | Zhang Yong | Department of Radiation Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China | | | Wang Rensheng | Department of Radiation Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China | 13807806008@163.com |
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| Abstract:: |
| Objective To evaluate the prognostic value of iASPP for nasopharyngeal carcinoma (NPC).Methods One hundred and thirty patients with nasopharyngeal carcinoma were initially diagnosed and treated between January and December 2012 in Department of Radiation Oncology of the First Affiliated Hospital of Guangxi Medical University. The clinical staging was classified according to the cancer staging criteria 2009 AJCC/UICC. All patients were treated by IMRT. Cisplatin-based concurrent chemotherapy was given to patients with stages Ⅲ-ⅣB disease. Immunohistochemistry was used to detect the expression of iASPP in the carcinoma tissues, and the clinicopathological features were compared among the patients with different expressions of iASPP. Furthermore, the relationship between the expression of iASPP and the efficacy in patients was explored. Results Of 130 patients, positive expression of iASPP was observed in 86 patients(66.2%), and negative expression in 44 patients(33.8%). There was significant difference in the positive expression rate of iASPP among the patients with different N-stage and clinical stages(χ2=7.565, 4.947, P<0.01). At three months after treatment, no significant difference was found in the response rate of tumor with different expression of iASPP. In univariate analysis, the expression of iASPP was significant predictor of 3 year-DMFS (χ2=4.335, P=0.037) and PFS (χ2=6.640, P=0.01). Furthermore, N-stage was significant predictor of 3y-DMFS (χ2=8.058, P=0.005), PFS (χ2=9.554, P=0.002) and OS (χ2=6.987, P=0.008), respectively. By using multivariate Cox analysis, the expression of iASPP and N-stage was independent prognostic factors for PFS(χ2=4.336, 5.228, P<0.05), respectively. Conclusions Positive expression of iASPP may be a poor prognostic factor for NPC patients. |
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