| Xia Chongsheng,Li Miaomiao,Fan Min,Liu Xiaomeng,Fu Chengrui,Dong Yinping,Li Baosheng,Huang Wei.Clinical outcome of early stage breast cancer treated with simultaneous integrated boost intensity-modulated radiation therapy after breast conserving surgery[J].Chinese Journal of Radiological Medicine and Protection,2017,37(2):119-124 |
| Clinical outcome of early stage breast cancer treated with simultaneous integrated boost intensity-modulated radiation therapy after breast conserving surgery |
| Received:October 18, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.02.007 |
| KeyWords:Breast neoplasms Breast-conserving surgery Simultaneous integrated boost intensity-modulated radiation therapy Curative effect Side-effects |
| FundProject: |
| Author Name | Affiliation | E-mail | | Xia Chongsheng | School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250200, China | | | Li Miaomiao | Shandong Medical College, Jinan 276000, China | | | Fan Min | Department of Radiation Oncology, Affiliated Shandong Cancer Hospital of Shandong University, 250117 Jinan, China | | | Liu Xiaomeng | Department of Radiation Oncology, Affiliated Shandong Cancer Hospital of Shandong University, 250117 Jinan, China | | | Fu Chengrui | Department of Radiation Oncology, Affiliated Shandong Cancer Hospital of Shandong University, 250117 Jinan, China | | | Dong Yinping | Department of Radiation Oncology, Affiliated Shandong Cancer Hospital of Shandong University, 250117 Jinan, China | | | Li Baosheng | Department of Radiation Oncology, Affiliated Shandong Cancer Hospital of Shandong University, 250117 Jinan, China | | | Huang Wei | Department of Radiation Oncology, Affiliated Shandong Cancer Hospital of Shandong University, 250117 Jinan, China | alvinbird@163.com |
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| Abstract:: |
| Objective To investigate the efficacy, toxicity and cosmetic outcome of simultaneous integrated boost intensity-modulated radiation therapy (SIB-IMRT) for early-stage breast cancer patients after breast-conserving surgery.Methods A total of 146 patients with T1-2N0-1M0 breast cancer after breast-conserving surgery were included. Of which, 60 patients received whole-breast radiation to 45-50 Gy in 25 fractions followed by tumor bed boost of 10-16 Gy in 5-8 fractions and the course of radiotherapy was 42-45 days (C group). The other 86 patients received whole breast radiation to 50.4 Gy in 28 fractions with concomitant tumor bed boost to 60.2 Gy in 28 fractions (S group). Kaplan-Meier method was used to calculate the overall survival rate and local recurrence rate. χ2-test was used to compared the differences of the clinical characteristics, toxicity and cosmetic outcome between the two groups. Results The incidence of grade 1 acute skin toxicity was 63.3% and 75.8%, grade 2 was 20.0% and 16.2%, grade 3 was 16.7% and 8.0% in C and S group (P>0.05), respectively.In C and S group, the incidence of grade 0 late skin and subcutaneous tissue toxicity was 84.6% and 85.8%, grade 1 was 12.2% and 10.6%, grade 2 was 3.2% and 3.6% (P>0.05), respectively. The incidence of grade 0 neutropenia was 22.6% and 33.7%, grade 1 was 34.6% and 40.7%, grade 2 was 26.7% and 20.9%, grade 3 was 15.0% and 4.7% in C and S group (P>0.05) , respectively.There were 89.7% and 89.2% of patients had excellent and good cosmetic outcome in C and S group, respectively (P>0.05), and 3.3% and 3.5% of patients experienced radiation pneumonitis (P>0.05). After a median follow up of 38 months (24-74 months), the follow-up rate was 95.2%. The 1-, 3- and 5-year overall survival rates were 100%.There were 3.5% and 3.7% of patients had local recurrence and/or distant metastatic in C and S group, respectively. Conclusions The efficacy, toxicity and cosmetic outcome of SB-IMRT and SIB-IMRT were similar. Compared with SB-IMRT, SIB-IMRT has an advantage of shortening the treatment period. |
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