| Bao Shana,Wang Wei,Lyu Xiaoming,Shi Yan,Zheng Lei,Zhang Jie,Zhang Jianguo.Clinical investigation on local and regional failure factors of salivary gland carcinoma treated by 125I seeds[J].Chinese Journal of Radiological Medicine and Protection,2017,37(2):114-118 |
| Clinical investigation on local and regional failure factors of salivary gland carcinoma treated by 125I seeds |
| Received:July 14, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.02.006 |
| KeyWords:Local and regional failure 125I seeds Salivary gland carcinoma Risk factors |
| FundProject: |
| Author Name | Affiliation | E-mail | | Bao Shana | Department of Oral and Maxillofacial Surgery, Peking University Hospital of Stomatology, Beijing 100081, China | | | Wang Wei | Department of Oral and Maxillofacial Surgery, Peking University Hospital of Stomatology, Beijing 100081, China | | | Lyu Xiaoming | Department of Oral and Maxillofacial Surgery, Peking University Hospital of Stomatology, Beijing 100081, China | | | Shi Yan | Department of Oral and Maxillofacial Surgery, Peking University Hospital of Stomatology, Beijing 100081, China | | | Zheng Lei | Department of Oral and Maxillofacial Surgery, Peking University Hospital of Stomatology, Beijing 100081, China | | | Zhang Jie | Department of Oral and Maxillofacial Surgery, Peking University Hospital of Stomatology, Beijing 100081, China | zhangjie06@126.com | | Zhang Jianguo | Department of Oral and Maxillofacial Surgery, Peking University Hospital of Stomatology, Beijing 100081, China | |
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| Abstract:: |
| Objective To summarize clinical features of local and regional failure of salivary gland carcinoma treating by 125I seed, and evaluate the clinical and histologic risk factors for its development.Methods Patients with salivary gland carcinoma treated by 125I seeds between Oct 2001 and Aug 2012 were analyzed retrospectively. The risk factors were analyzed statistically, including age, gender, tumor site, TNM stage, histological differentiation, radiotherapy, treatment, matched peripheral dose and primary or recurrent tumor. Results Ninety-four of 449 patients with salivary gland carcinoma treated by 125I seeds developed local and/or regional area recurrence. Of these, six patients failed in both local and regional area, 77 patients failed in local area and eleven patients failed in regional area. The local and regional failure rate was 20.9%. The result of multivariate analysis showed that surgery, radiotherapy and matched peripheral dose were the protective factors(OR=0.458, 0.297, 0.982,P<0.05), while age and TNM stage were the risk factors(OR=1.250, 1.483, P<0.05). Conclusions The local and regional failure rate was 20.9%. Surgery, radiotherapy and matched peripheral dose were the protective factors; age and TNM stage were the risk factors. |
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