| Zang Wanna,Su Jingwei,Zhu Shuchai,Zhao Yan,Song Chunyang,Xu Jinrui.A comparative study of resection plus chemotherapy and chemoradiotherapy in limited-stage small cell lung cancer[J].Chinese Journal of Radiological Medicine and Protection,2017,37(1):40-44 |
| A comparative study of resection plus chemotherapy and chemoradiotherapy in limited-stage small cell lung cancer |
| Received:June 06, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.01.008 |
| KeyWords:Limited-disease Small cell lung cancer Resection plus chemotherapy Chemoradiotherapy Prognostic |
| FundProject: |
| Author Name | Affiliation | E-mail | | Zang Wanna | Department of Oncology, No. 4 People's Hospital of Hengshui, Hengshui 053000, China | | | Su Jingwei | Department of Radiation, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Zhu Shuchai | Department of Radiation, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | sczhu1965@163.com | | Zhao Yan | Department of Radiation, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Song Chunyang | Department of Radiation, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Xu Jinrui | Department of Radiation, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | |
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| Abstract:: |
| Objective The aim of this study was to evaluate the prognosis of resection followed by chemotherapy compared with chemoradiotherapy for limited-stage small cell lung cancer.Methods The clinical data of 230 limited-stage small cell lung cancer patients with curative treatment between January 2006 and December 2011 were retrospectively analyzed. All patients divided to two group:the resection plus chemotherapy (S+C) and chemoradiotherapy (R+C). And the prognostic factors were further analyzed with limited stage small cell lung cancer. The Kaplan-Meier method was used for the survival analysis. Results The overall survival rates of 1-year, 3-year and 5-year were 87.0%, 38.9%, 25.4%, respectively and the media survival time (MST) 26.0 months. When patients were stratified by clinical stage Ⅰ+Ⅱ, the 1-year, 3-year and 5-year overall survival rates of S+C group and R+C group were 92.6%, 63.2%, 47.3% and 76.2%, 42.9%, 30.6%, respectively (χ2=7.851,P<0.05), while those were 88.5%, 26.9%, 10.6% and 86.0%, 25.1%, 25.1%, respectively in stage ⅢA with no significant difference(P>0.05). In univariate analysis, tumor location, tumor stage, lymph node metastasis, TNM stage, the cycle of chemotherapy, treatment modalities were significantly associated with survival (RR=1.735, P<0.05).The multivariate analysis only showed TNM stage were independent factors of prognosis. Conclusions The results suggested that resection plus chemotherapy could improve the prognosis of early-stage(stageⅠ+Ⅱ) small cell lung cancer, but patients in ⅢA stage should received the definitive chemoradiotherapy. The TNM stage was still the independent factor of prognosis. |
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