| Wang Zhenzhen,Wang Haitao,Gao Guangkai,Chen Hao,Wang Bin.Effect of compound raspberry seed powder on acute radiation injury[J].Chinese Journal of Radiological Medicine and Protection,2017,37(1):24-28 |
| Effect of compound raspberry seed powder on acute radiation injury |
| Received:May 31, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.01.005 |
| KeyWords:Compound raspberry seed powder X-rays Radiation injury Superoxide dismutase Glutathione peroxidase |
| FundProject: |
| Author Name | Affiliation | E-mail | | Wang Zhenzhen | Department of Special Medicine, School of Medicine, Qingdao University, Qingdao 266071, China | | | Wang Haitao | Department of Occupational Health, School of Public Health, Qingdao University, Qingdao 266071, China | | | Gao Guangkai | Department of Hyperbaric Medicine, No. 401 Hospital of PLA, Qingdao 266071, China | | | Chen Hao | Department of Special Medicine, School of Medicine, Qingdao University, Qingdao 266071, China | | | Wang Bin | Graduate School, Qingdao University, Qingdao 266071, China | wangbin532@126.com |
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| Abstract:: |
| Objective To study the protective effect of compound raspberry seed powder on acute irradiated rat.Methods Totally forty Wistar rats were randomized divided into four groups:normal control group, radiation group, vitamin group, compound raspberry seed powder group. The drugs were intragastrically administrated for 7 days. On 8th day, the rats in each group except control were irradiated with 8 Gy X-rays. 24 h after irradiation, all rats were sacrificed and its WBC, PLT, superoxide dismutases (SOD), malonaldehyde (MDA), glutathione peroxidase (GSH-PX) in serum were detected, the DNA damage in peripheral blood lymphocytes (PBL) was measured with the single cell gel electrophoresis technique. Results Compared with radiation alone group, the quantities of WBC, PLT, the activity of SOD, the content of MDA and the activity of GSH-PX in the vitamin group and compound raspberry seed powder group were significantly improved(F=14.869, 6.376, 7.705, 3.851, 3.134, P<0.05). The DNA damage in PBL of radiation alone group was more severe than that of other three groups(F=5.493, P<0.05). Conclusions Raspberry seed powder is effective in radiation protection. |
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