| Zhao Mingxiao,Bao Xiebing,Chen Huaiyuan,Wu Xiaojin,Wang Chang.Preliminary study on plasma metabolites of total body irradiation patients[J].Chinese Journal of Radiological Medicine and Protection,2017,37(1):7-11 |
| Preliminary study on plasma metabolites of total body irradiation patients |
| Received:September 27, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.01.002 |
| KeyWords:Total body irradiation (TBI) Radiation damage Metabonomics Gas chromatography-mass spectrometry (GC-MS) Plasma |
| FundProject:国家自然科学基金（31000385）；江苏省高校优势学科建设工程资助项目（PAPD） |
| Author Name | Affiliation | E-mail | | Zhao Mingxiao | School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou 215000, China | | | Bao Xiebing | First Affiliated Hospital of Soochow University, Suzhou 215000, China | | | Chen Huaiyuan | School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou 215000, China | | | Wu Xiaojin | First Affiliated Hospital of Soochow University, Suzhou 215000, China | | | Wang Chang | School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou 215000, China | wangchang@suda.edu.cn |
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| Abstract:: |
| Objective To investigate radiation-related human plasma metabolic features by using metabonomics method and to analyze relative metabolic pathway.Methods The plasma samples of 40 patients pre-and post-total body irradiation (TBI) from January 2012 to May 2014 were collected, and the effect of TBI on human plasma metabolites was studied by gas chromatography mass spectrometry (GC-MS), and the differential plasma metabolic features related to irradiation damage were screened. Results The levels of glucose, myristic acid, oxalic acid, 3-hydroxy butyric acid, urea, aspartic acid, valine, leucine, lysine and threonine in plasma were significantly(P<0.05) increased after TBI, while the levels of cholesterol, pyruvic acid, propionic acid, lactic acid, alanine, glycine, inositol, sorbitan, ethylene glycol and hypoxanthine were decreased drastically(P<0.05).Conclusions TBI could cause significant changes in the levels of human plasma metabolites including amino acid metabolism, glucose metabolism, lipid metabolism and so on. |
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