| Zhang Pinhua,Gao Gang,Pan Yan,Tian Mei,Wu Lina,Piao Chunnan,Ruan Jianlei,Liu Jianxiang.MicroRNA expressions in peripheral blood plasma of the residents from high background radiation area of Yangjiang, China[J].Chinese Journal of Radiological Medicine and Protection,2017,37(1):1-6 |
| MicroRNA expressions in peripheral blood plasma of the residents from high background radiation area of Yangjiang, China |
| Received:August 24, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.01.001 |
| KeyWords:High background Low dose radiation miRNAs Plasma Biomarker |
| FundProject:国家自然科学基金（31000385）；江苏省高校优势学科建设工程资助项目（PAPD） |
| Author Name | Affiliation | E-mail | | Zhang Pinhua | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Gao Gang | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Pan Yan | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Tian Mei | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Wu Lina | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Piao Chunnan | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Ruan Jianlei | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Liu Jianxiang | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | jxliu@163.com |
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| Abstract:: |
| Objective To explore the effects of high background radiation on the expressions of miR-16, miR-106b, miR-449a, miR-34a and let-7g in peripheral blood plasma of the residents.Methods Totally 110 healthy female long-term local residents aged over 50 years were randomly selected from the high background radiation area and the control area, while their age, body mass index(BMI) and other indicators were surveyed. The relative expression levels of miRNAs in peripheral blood plasma of these women were quantitatively detected by real-time fluorescence quantitative PCR (RT-PCR). Then t-test was used to analyze the cumulative dose, age and BMI between the high background and control group. Mann-Whitney U-test was used for statistical analysis of miRNA expression levels between two groups, and the multiple regression analysis was used finally. Results Compared with the control group, the cumulative dose of individuals in the high background group was about four times higher (t=42.803, P<0.05), and the levels of miR-16 and miR-106b in plasma of high background group were down-regulated, while the level of miR-449a was up-regulated (Z=4.180, 2.422, 2.794, P<0.05). After controlling of confounding factors such as age and BMI, the expression levels of miR-16 and miR-106b were negatively correlated with the cumulative dose of individuals (P<0.05). On the contrary, no significant correlation was observed between the levels of miR-449a, miR-34a, let-7g and the individual cumulative dose (P>0.05). Conclusions miR-16 and miR-106b may serve as biomarkers for the early stage of low dose radiation health effects. |
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