| Wu Jianwei,Li Xiaofan,Li Yongheng,Cai Yong.Safety assessment for radiotherapy combined with chemotherapy or not in 63 elderly patients with gastric cancer[J].Chinese Journal of Radiological Medicine and Protection,2016,36(11):827-831 |
| Safety assessment for radiotherapy combined with chemotherapy or not in 63 elderly patients with gastric cancer |
| Received:July 20, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.11.006 |
| KeyWords:Gastric cancer Elderly patients Radiotherapy Chemoradiotherapy Toxicity |
| FundProject: |
| Author Name | Affiliation | E-mail | | Wu Jianwei | Key Laboratory of Carcinogenesis and Translational Research(Peking University) Ministry of Education, Beijing Cancer Hospital & Beijing Institute for Cancer Research, Beijing 100142, China | | | Li Xiaofan | Key Laboratory of Carcinogenesis and Translational Research(Peking University) Ministry of Education, Beijing Cancer Hospital & Beijing Institute for Cancer Research, Beijing 100142, China | | | Li Yongheng | Key Laboratory of Carcinogenesis and Translational Research(Peking University) Ministry of Education, Beijing Cancer Hospital & Beijing Institute for Cancer Research, Beijing 100142, China | | | Cai Yong | Key Laboratory of Carcinogenesis and Translational Research(Peking University) Ministry of Education, Beijing Cancer Hospital & Beijing Institute for Cancer Research, Beijing 100142, China | caiyong109@sohu.com |
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| Abstract:: |
| Objective To investigate the safety of external beam radiotherapy for elderly patients with gastric cancer. Methods This retrospective study included 63 histologically confirmed gastric cancer patients aged over 70 years(48 males and 15 females), with a median age of 74 (70-85) years, whose American Joint Committee on Cancer Staging(AJCC) Stage ranged from Ⅰb to Ⅳ at Beijing Cancer Hospital between March 2009 and December 2014. The median radiation dose was 50(16-60) Gy and the median radiation duration was 36 (11-73) days, concurrently combined with chemotherapy based on fluoropyimidine or not. The completion of radiation, toxicities, evaluations of short-term effect, and 1, 2-year overall survival rates were surveyed and analyzed. Compared the survival and the toxicity in chemoradiotherapy arm and radiotherapy arm. Results Of the total 63 patients, radiotherapy had been completed in 51 patients (81.0%). The incidence of grade 3 or greater acute toxicity as noted was 19.0% of patients (12/63), which included hematologic toxicity 9.5% (6/63) and upper gastrointestinal tract toxicity 9.5% (6/63). The responses to radiotherapy and chemoradiotherapy were evaluated on 56 patients. The complete response (CR) rate was 7.1% (4/56), partial response (PR) rate was 39.3% (22/56), and stable disease (SD) rate was 9.3% (22/56). The duration of follow-up time was 1.5-69 months and median duration was 17 months. The survival time was 6.9-21.1 months and median survival time was 17 months. The 1- and 2-year overall survival rate was 55.0% (95% CI48.6%-61.4%) and 36.2% (95% CI29.2%-43.2%), respectively. There was no significant difference between chemoradiotherapy and radiotherapy arms in terms of survival time (median survival:20.5 months vs.12 months, P>0.05), as well as toxicity (P>0.05). Conclusions The toxicity of radiotherapy and chemoradiotherapy for elderly patients with gastric cancer is acceptable, and the effectiveness of the treatment is satisfactory. |
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