| Song Shujun,Si Shaoyan,Liu Junli,Zuo Xiaoyong,Wang Ying,Guo Yanchuan,Shan Gaixian,Wang Zongye.The effect of the collagen peptides on the immune function of X-ray irradiated mice[J].Chinese Journal of Radiological Medicine and Protection,2016,36(11):811-814 |
| The effect of the collagen peptides on the immune function of X-ray irradiated mice |
| Received:July 12, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.11.003 |
| KeyWords:Collagen peptides Immune function X-rays |
| FundProject: |
| Author Name | Affiliation | E-mail | | Song Shujun | Center for Special Medicine and Experimental Research, No. 306 Hospital of PLA, Beijing 100101, China | | | Si Shaoyan | Center for Special Medicine and Experimental Research, No. 306 Hospital of PLA, Beijing 100101, China | | | Liu Junli | Center for Special Medicine and Experimental Research, No. 306 Hospital of PLA, Beijing 100101, China | | | Zuo Xiaoyong | Center for Therapeutic Radiology and Oncology, No. 306 Hospital of PLA, Beijing 100101, China | | | Wang Ying | Center for Therapeutic Radiology and Oncology, No. 306 Hospital of PLA, Beijing 100101, China | | | Guo Yanchuan | Technical Institute of Physics and Chemistry, Chinese Academy of Science, Beijing 100190, China | | | Shan Gaixian | Center for Therapeutic Radiology and Oncology, No. 306 Hospital of PLA, Beijing 100101, China | | | Wang Zongye | Center for Therapeutic Radiology and Oncology, No. 306 Hospital of PLA, Beijing 100101, China | wangzye@163.com |
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| Abstract:: |
| Objective To study the effects of collagen peptides(CP) on the immune functions of X-ray irradiated mice. Methods ICE mice were randomly divided into five groups according to body weight:control, 2 Gy, 5 Gy, 2 Gy CP (2 Gy X-ray irradiation & administrated with collagen peptides 600 mg·kg-1·d-1) and 5 Gy CP (5 Gy X-ray irradiation & administrated with collagen peptides 600 mg·kg-1·d-1) groups. Immunosuppressant mouse model was established by iradiating ICE mice with 6 MV of X-rays generated by a linear accelerator, where the whole body of the mice was irradiated with a single dose of 2 Gy or 5 Gy at dose rate of 6 Gy/min. And the mice in groups of 2 and 5 Gy CP were injected intraperitoneally with collagen peptides (600 mg·kg-1·d-1) for 7 days after irradiation. On the day 8, the mice were decapitated. The body weights, thymus and spleen indexes, IL-2 level and proliferations of spleen T lymphocytes induced by ConA were detected. Results Compared with the control group, the thymus and spleen indexes, the level of IL-2 and proliferations of spleen T lymphocytes were significantly decreased(F=76.857, 181.870, 63.133, 8.499, P<0.05). These parameters were restored to some extent in mice injected with collagen peptides when compared with the mice irradiated with same dose of X-rays. Conclusion Peritoneal injection of collagen peptides can enhance the immune functions in X-ray irradiated mice. |
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