| Ding Xin,Tian Ye.Research status of hippocampal dysfunctions caused by cranial irradiation[J].Chinese Journal of Radiological Medicine and Protection,2016,36(9):712-716 |
| Research status of hippocampal dysfunctions caused by cranial irradiation |
| Received:April 18, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.09.017 |
| KeyWords:Cranial radiation Hippocampal dysfunction Neurogenesis |
| FundProject:国家自然科学基金（81372411，81402517） |
| Author Name | Affiliation | E-mail | | Ding Xin | Department of Radiotherapy & Oncology, Second Affiliated Hospital of Soochow University, Institute of Radiotherapy & Oncology, Soochow University, Suzhou Key Laboratory for Radiation Oncology, Suzhou 215004, China | | | Tian Ye | Department of Radiotherapy & Oncology, Second Affiliated Hospital of Soochow University, Institute of Radiotherapy & Oncology, Soochow University, Suzhou Key Laboratory for Radiation Oncology, Suzhou 215004, China | dryetian@126.com |
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| Abstract:: |
| Cranial irradiation is routinely used for the treatment of almost all brain tumors, but it may cause disastrous injury in brain, especially in the hippocampus that has cognitional and emotional regulation functions. Several studies have investigated the mechanisms of radiation-induced hippocampal dysfunctions such as hippocampal neurogenesis, neurotrophin and neuroinflammation, and provided effective prevention strategies such as exercise, environmental enrichment, anti-inflammatory and intrahippocampal transplantation of neural stem cells. This review discussed the current progresses and challenges of hippocampal dysfunction induced by cranial irradiation and provided new insights for preclinical and clinical researches. |
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