| Wang Jingsheng,Zhuang Hongqing,Li Fengtong,et al.The efficacy of bevacizumab on the treatment of cerebral radiation necrosis[J].Chinese Journal of Radiological Medicine and Protection,2016,36(9):678-681 |
| The efficacy of bevacizumab on the treatment of cerebral radiation necrosis |
| Received:April 11, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.09.008 |
| KeyWords:Bevacizumab Cerebral radiation necrosis Cyberknife Stereotactic radiotherapy |
| FundProject:国家自然科学基金（11375048） |
| Author Name | Affiliation | E-mail | | Wang Jingsheng | Department of Radiotherapy, Tianjin Medical University Cancer Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China | | | Zhuang Hongqing | Department of Radiotherapy, Tianjin Medical University Cancer Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China | hongqingzhuang@163.com | | Li Fengtong | Department of Radiotherapy, Tianjin Medical University Cancer Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China | | | Dong Yang | Department of Radiotherapy, Tianjin Medical University Cancer Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China | | | Chen Huaming | Department of Radiotherapy, Tianjin Medical University Cancer Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China | | | Song Yongchun | Department of Radiotherapy, Tianjin Medical University Cancer Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China | | | Wang Xiaoguang | Department of Radiotherapy, Tianjin Medical University Cancer Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China | | | Yuan Zhiyong | Department of Radiotherapy, Tianjin Medical University Cancer Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China | |
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| Abstract:: |
| Objective To evaluate the efficacy of bevacizumab on the treatment of cerebral radiation necrosis. Methods 14 cases were collected from June 2011 to February 2013 in Tianjin Medical Cancer Hospital, who were diagnosed as cerebral radiation necrosis. Patients were treated with bevacizumab a dose of 5 mg/kg, once every 3 weeks, at least 3 times. The changes of symptoms of brain necrosis, the volume of intracranial edema, the volume of brain necrosis, and the MRI signal changes were used as the first observation points. The adverse reactions of bevacizumab were used as the second observation points. Results The edema index, brain necrosis volume, MRI signal ratio before and after bevacizumab treatment brain necrosis lesions were 7.05±6.48, (55.96±32.91) ml, 2.70±4.78 and 3.59±4.74, (26.99±31.40) ml, 1.82±0.53, respectively, with statistical significant differences between the two groups (t=3.946, 3.952, 4.507, P<0.01). The adverse reaction of bevacizumab was less, and there were no more than 2 degree adverse reactions. Conclusions Bevacizumab is effective and safe in the treatment of cerebral radiation necrosis, worthy of further study. |
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