| Wang Xiaohu,Tian Jinhui,Zhang Qiuning,et al.A Meta-analysis of carbon ion radiotherapy for prostate cancer[WTBX][J].Chinese Journal of Radiological Medicine and Protection,2016,36(8):588-593 |
| A Meta-analysis of carbon ion radiotherapy for prostate cancer[WTBX] |
| Received:March 22, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.08.007 |
| KeyWords:Carbon ion Prostate cancer Meta-analysis |
| FundProject:国家自然科学基金（81160283，81372419）；甘肃省科技厅科技创新团队资助项目（09877CA009） |
| Author Name | Affiliation | | Wang Xiaohu | Gansu Provincial Academic Institute for Medical Research, Gansu Provincial Cancer Hospital, 730050 Lanzhou, China | | Tian Jinhui | Gansu Provincial Academic Institute for Medical Research, Gansu Provincial Cancer Hospital, 730050 Lanzhou, China | | Zhang Qiuning | Gansu Provincial Academic Institute for Medical Research, Gansu Provincial Cancer Hospital, 730050 Lanzhou, China | | Li Qianru | Second College of Clinical Medicine, Lanzhou University, Lanzhou 730000 | | Zhang Hong | Institute of Modern Physics, Chinese Academy of Science, Lanzhou 730000, China | | Zhao Lin | Gansu Provincial Academic Institute for Medical Research, Gansu Provincial Cancer Hospital, 730050 Lanzhou, China |
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| Abstract:: |
| Objective To evaluate the efficacy of the carbon ion radiotherapy for prostate cancer by Meta-analysis. Methods We searched the Cochrane library, PubMed, EMBASE, China Journal Full-text Database, Chinese Biomedical Database, and Wanfang Database from their inception to December 2015, in order to collect clinical trial data of carbon ion radiotherapy for prostate cancer. References included within these studies were also retrieved. Meta-analysis was performed using MetaAnalyst Beta 3.13 and STATA 12.0 software. Results Six studies (eight clinical trials) were included. The results of Meta-analysis show that, the overall survival rates of 3,4,5 and 8 years were 95.7%, 90.9%, 91.8% and 83.9%, respectively. The cause specific survival rate of 4 and 5 years were 97.1% and 97.6%. The bNED rate of 3,4,5 and 8 years were 88%, 86.3% and 79.1%, respectively. The local control rates of 3, 4 and 5 years were 98.1%, 97.1% and 98.4%, respectively. The rate of total death, prostate cancer death and intercurrent death were 7%, 2.4% and 7%, respectively. Different T-stage may affect the five-year of overall survival rate, bNED rate and cause specific survival rate. Conclusions The current evidence shows that carbon ion radiotherapy in general is a feasible treatment for prostate cancer, whether carbon ion is better than other radiotherapy, prospective, randomized, controlled clinical trial to get more evidence is required for carbon ion radiotherapy versus standard treatment for prostate cancer patients. |
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