| Dai Hong,Liu Yulong,Wang Youyou,et al.Dynamic analysis on three indexes of biological dose estimation of the victim exposed to 192Ir radiation source at “5.7” accident in Nanjing[J].Chinese Journal of Radiological Medicine and Protection,2016,36(5):355-358 |
| Dynamic analysis on three indexes of biological dose estimation of the victim exposed to 192Ir radiation source at “5.7” accident in Nanjing |
| Received:February 05, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.05.009 |
| KeyWords:192Ir Biological dose estimation Chromosomal aberrations Micronuclei Nucleoplasmic bridges |
| FundProject:江苏省临床医学科技专项(BL2014040);江苏省卫生计生委2014-2015年度预防医学科研项目(Y2015024);江苏省研究生培养创新工程项目(SJLX15-0580) |
| Author Name | Affiliation | E-mail | | Dai Hong | Department of Nuclear Emergency Center, Second Affiliated Hospital of Soochow University, Suzhou 215004, China | | | Liu Yulong | Department of Nuclear Emergency Center, Second Affiliated Hospital of Soochow University, Suzhou 215004, China | yulongliu2002@126.com | | Wang Youyou | Department of Nuclear Emergency Center, Second Affiliated Hospital of Soochow University, Suzhou 215004, China | | | Feng Junchao | Department of Nuclear Emergency Center, Second Affiliated Hospital of Soochow University, Suzhou 215004, China | | | Zhao Hua | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Protection, Beijing 100088, China | | | Liu Qingjie | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Protection, Beijing 100088, China | | | Guo Kailin | Department of Nuclear Emergency Center, Second Affiliated Hospital of Soochow University, Suzhou 215004, China | |
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| Abstract:: |
| Objective To explore the natural attenuation pattern of three biological dose estimation indexes in vivo by investigating the effect on biological dosimetry of peripheral blood sampling at different time points from the victim partially exposed to 192Ir radiation source at "5.7" accident in Nanjing.Methods Peripheral blood of the patient was collected on days 5, 40 and 280 after exposure, respectively. The yields of dicentrics plus rings chromosomes ("dic+r"), cytokinesis-block micronuclei (CBMN) and nucleoplasmic bridge+fusion+horse shoe+circular(NPB+FHC) were analyzed. The dynamic reduction and dose estimation were both observed using the biomarkers mentioned above after exposure. Results Compared to the estimates on days 5 after exposure, the dose values estimated on days 40 and 280 decreased by 34% and 49% for "dic+r" method, 48% and 79% for the CBMN assay, and 48% and 75% for NPN+FHC method, respectively. Conclusions Three biological dose estimation indexes show a progressive decrease in vivo, with the half-life of "dic+r"/cell being 40 days. The doses estimated using these three indexes on days 40 after exposure showed a relative deviation more than 20% compared with those on days 5 after exposure. |
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