| Dai Hong,Liu Yulong,Wang Youyou,et al.Biological dosimetry for the victim accidentally exposed to 192Ir radiation source at “5.7” accident in Nanjing[J].Chinese Journal of Radiological Medicine and Protection,2016,36(5):350-354 |
| Biological dosimetry for the victim accidentally exposed to 192Ir radiation source at “5.7” accident in Nanjing |
| Received:February 05, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.05.008 |
| KeyWords:192Ir radiation accident Biological dose estimation Chromosomal aberrations Micronuclei Nucleoplasmic bridges |
| FundProject:江苏省临床医学科技专项(BL2014040);江苏省卫生计生委2014-2015年度预防医学科研项目(Y2015024);江苏省研究生培养创新工程项目(SJLX15-0580) |
| Author Name | Affiliation | E-mail | | Dai Hong | Department of Nuclear Emergency Center, Second Affiliated Hospital of Soochow University, Suzhou 215004, China | | | Liu Yulong | Department of Nuclear Emergency Center, Second Affiliated Hospital of Soochow University, Suzhou 215004, China | yulongliu2002@126.com | | Wang Youyou | Department of Nuclear Emergency Center, Second Affiliated Hospital of Soochow University, Suzhou 215004, China | | | Feng Junchao | Department of Nuclear Emergency Center, Second Affiliated Hospital of Soochow University, Suzhou 215004, China | | | Zhao Hua | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Protection, Beijing 100088, China | | | Liu Qingjie | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Protection, Beijing 100088, China | | | Guo Kailin | Department of Nuclear Emergency Center, Second Affiliated Hospital of Soochow University, Suzhou 215004, China | |
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| Abstract:: |
| Objective To use three different methods in attempt to estimate the biological dose of the patient partially exposed to 192Ir source at "5.7" accident in Nanjing, so as to provide dosimetric information for clinical remedy of exposed patients in the emergency of a nuclear accident. Methods Peripheral blood samples were collected on days 5 after exposure. The biological dose was estimated by the yields of dicentrics plus rings ("dic+r"), cytokinesis-block micronuclei (CBMN) assay and nucleoplasmic bridge plus FHC (NPB+FHC). The homogeneity of radiation exposure was examined by Poisson distribution of dicentrics. Results By using three different methods, the whole body equivalent dose was "dic+r" estimated to be 1.51 Gy (95%CI 1.40-1.61), 1.47 Gy (95%CI 1.36-1.60) by CBMN and 1.30 Gy (95%CI 1.00-1.60) by NPB+FHC, respectively. A non-poisson distribution was also detected, suggesting partial body radiation exposure. Conclusions The estimated whole body equivalent dose of a non-uniform radiation exposure was consistent with clinical diagnosis, suggesting that the yields of "dic+r", CBMN, as well as NPB+FHC, are efficient approaches to the estimation of biological doses. |
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