| Chen Xi,Zhao Lujun,Xu Liming,et al.Research progress of oxidative stress in radiation-induced lung injury[J].Chinese Journal of Radiological Medicine and Protection,2016,36(4):312-315 |
| Research progress of oxidative stress in radiation-induced lung injury |
| Received:November 11, 2015 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.04.017 |
| KeyWords:Oxidative stress Radiation-induced lung injury Reactive oxygen species |
| FundProject:国家自然科学基金(30970864) |
| Author Name | Affiliation | E-mail | | Chen Xi | Department of Radiation Oncology, Tianjin Medical University Cancer Institnte and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin 300060, China | | | Zhao Lujun | Department of Radiation Oncology, Tianjin Medical University Cancer Institnte and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin 300060, China | | | Xu Liming | Department of Radiation Oncology, Tianjin Medical University Cancer Institnte and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin 300060, China | | | Wang Ping | Department of Radiation Oncology, Tianjin Medical University Cancer Institnte and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin 300060, China | tjdoctorwang@163.com |
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| Abstract:: |
| Although it has been frequently used to treat thoraxic tumors, radiation induced lung injury (RILI) is the major factor of dose limitation in thoracic radiotherapy. Amount of endogenous and exogenous reactive oxygen/nitrogen species (ROS/RNOS) could be generated in the radiated organisms and further cause molecular damage of DNA, protein and membrane lipids, which results in celluar structure damage, dysfunction and RILI. In addition, a series of cytokines could also induce chronic oxidative stresses that contribute to increases in cell membrane permeability, tissue edema and extracellular matrix proteins accumulation and even further result in pulmonary fibrosis. Oxidative stress theory offers new clues and strategies for further understanding the mechanism of RILI, and some anti-oxidative stress drugs may have potential clincial application in RILI treatment. |
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