| Lin Hongmei,Shi Anhui,Sui Xin,et al.Prediction of GTV/LV for radiation pneumonitis in patients with stage Ⅲ non-small cell lung cancer after radical radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2016,36(4):272-277 |
| Prediction of GTV/LV for radiation pneumonitis in patients with stage Ⅲ non-small cell lung cancer after radical radiotherapy |
| Received:January 07, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.04.008 |
| KeyWords:Non-small cell lung cancer Radiotherapy Radiation pneumonitis Gross target volume Lung volume |
| FundProject:北京市医院管理局临床医学发展专项(ZYLX201509);吴阶平医学基金会资助项目(WKJ055-3-006) |
| Author Name | Affiliation | E-mail | | Lin Hongmei | Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Shi Anhui | Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Sui Xin | Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Yu Rong | Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Yu Huiming | Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Ma Huimin | Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Zhu Guangying | Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | zgypu163@163.com |
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| Abstract:: |
| Objective To analyze relevant clinical and dosimetric factors associated with radiation pneumonitis in patients with stage Ⅲ non-small cell lung cancer after they received radical radiotherapy. Methods A total of 126 patients with stage Ⅲ non-small cell lung cancer who received precision radiotherapy in Peking University Cancer Hospital were analyzed from January 2013 to December 2014. Data were collected including various clinical factors (including sex, age, histological type, tumor location, history of diabetes, history of hypertension, history of smoking, the season patients received treatment, ECOG performance status before treatment, chemotherapy before radiotherapy, concurrent chemotherapy and the classification of radiation pneumonitis), as well as related dosimetric parameters [including GTV, lung volume (LV), bilateral V5, V10, V20, V30 and MLD]. SPSS 19.0 software was used to analyze the relation between correlation factors and radiation pneumonitis (RP≥2). Results Among the patients, 31 cases (24.6%) had occurrance of radiation pneumonitis≥2. Univariate analysis showed that age, ECOG performance status before treatment, concurrent chemotherapy and GTV/LV ratio were significantly correlated with RP≥2 (R=0.157-0.222,P<0.05). Further multivariate Logistic regression showed that age, concurrent chemotherapy and GTV/LV ratio were significantly correlated(Wald=4.754,6.422,14.79,P<0.05). Conclusions In patients with stage Ⅲ non-small cell lung cancer after receiving thoracic radical radiotherapy, increasing age and GTV/LV ratio≥3.2% are risk factors of RP≥2. The concurrent chemotherapy with low-dose paclitaxel might also increase the risk of RP≥2. |
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