| Zhang Wei,Luo Yi,Li Jieqing,et al.Effects of long term exposure of 18F-FDG-PET/CT on rabbit immune system[J].Chinese Journal of Radiological Medicine and Protection,2016,36(4):264-267 |
| Effects of long term exposure of 18F-FDG-PET/CT on rabbit immune system |
| Received:July 02, 2015 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.04.006 |
| KeyWords:18F-FDG-PET/CT Long-term irradiation Immune system |
| FundProject:北京市医院管理局临床医学发展专项(ZYLX201509) |
| Author Name | Affiliation | E-mail | | Zhang Wei | Institute of Radiological Protection and Safety, Shandong Center for Disease Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan 250014, China | | | Luo Yi | Department of Radiology, Qianfoshan Hospital of Shandong Province, Jinan 2500014, China | | | Li Jieqing | Institute of Radiation Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China | | | Liu Yi | Institute of Radiological Protection and Safety, Shandong Center for Disease Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan 250014, China | lyyl0414@163.com |
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| Abstract:: |
| Objective To investigate the effects of long term exposure of 18F-FDG-PET/CT X-rays on rabbit immune system. Methods The rabbits were irradiated with 18F-FDG-PET/CT every day and this irradiation treatment continued for 3 months. At each month, the total number of white blood cells, thymus index and spleen index, phagocytic index, immune globulins, TNF-α and IL-1 in peripheral blood and serum were detected. Results After long-term 18F-FDG-PET/CT irradiation, the total number of white blood cells increased, the thymus and spleen index decreased (t=3.144-72.903, P<0.05), the phagocytic index and phagocytic percentage decreased after 1 or 2 months(t=2.719-11.859, P<0.05), and the number of immune cells marked with CD4+ increased but CD8+ decreased(t=6.433-29.877, P<0.05). In addition, the level of immune globulin in the serum decreased, but the expressions of TNF-α and IL-1β increased (t=2.720-28.775, P<0.05). Conclusions 18F-FDG-PET/CT has some damage effects on the immune system of male Japanese big ear rabbit, suggesting that the negative effects of PET-CT should be paid close attention to during clinical application. |
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