| Cai Shang,Tian Ye,Xu Bo.Recent progress in the combination treatment of radiotherapy and PD-1/PD-L1 signaling blockade immunotherapy[J].Chinese Journal of Radiological Medicine and Protection,2016,36(3):235-240 |
| Recent progress in the combination treatment of radiotherapy and PD-1/PD-L1 signaling blockade immunotherapy |
| Received:September 29, 2015 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.03.015 |
| KeyWords:Radiotherapy PD-1/PD-L1 signal blockade Oncology immunotherapy |
| FundProject: |
| Author Name | Affiliation | E-mail | | Cai Shang | Department of Radiotherapy & Oncology, Second Affiliated Hospital of Soochow University, Institute of Radiotherapy & Oncology, Soochow University, Suzhou Key Laboratory for Radiation Oncology, Suzhou 215004, China | | | Tian Ye | Department of Radiotherapy & Oncology, Second Affiliated Hospital of Soochow University, Institute of Radiotherapy & Oncology, Soochow University, Suzhou Key Laboratory for Radiation Oncology, Suzhou 215004, China | | | Xu Bo | Department of Oncology, Southern Research Institute, Birmingham, AL 35205, USA | bxu@uab.edu |
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| Abstract:: |
| Every stage of tumor initiation and development closely relates to immune regulation as tumor cells tend to evade attacks from immune system by employing the programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) interaction. Therefore, targeting the PD-1/PD-L1 pathway has become an attractive approach for cancer immunotherapy. Radiotherapy has long been considered a local tumor treatment modality and it is immune-inhibitory. However, accumulated evidence has shown that radiotherapy might enhance immune function by eliminating the tumor mass and has become a systemic tumor treatment modality. These observations indicate a strong rationale that the radiotherapy and anti-PD-1 and anti-PD-L1 immunotherapy may work synergistically to provide a powerful anti-tumor effect. This review discusses current progresses, challenges and perspectives of this novel combination treatment modality. |
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