| Yang Jianhua,Yang Lianhong,Wu Rong,et al.Efficacy of pregabalin in patients with painful radiation-induced brachial plexus injury[J].Chinese Journal of Radiological Medicine and Protection,2015,35(12):925-928 |
| Efficacy of pregabalin in patients with painful radiation-induced brachial plexus injury |
| Received:July 20, 2015 |
| DOI：10.3760/cma.j.issn.0254-5098.2015.12.009 |
| KeyWords:Radiation-induced pain Brachial plexus injury Pregabalin |
| FundProject:国家自然科学基金(81471249,81272576) |
| Author Name | Affiliation | E-mail | | Yang Jianhua | Department of neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China | | | Yang Lianhong | Department of neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China | docylh@163.com | | Wu Rong | Department of neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China | | | Xu Yongteng | Department of neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China | | | Cheng Jinping | Department of neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China | | | Tang Yamei | Department of neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China | |
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| Abstract:: |
| Objective To evaluate the efficacy of pregabalin on painful radiation-induced brachial plexus injury. Methods A total of forty-five patients with painful radiation-induced brachial plexus injury were assigned to treatment group with pregabalin 150-600 mg/d combined with conventional therapy, and to control group with conventional treatment for 12 weeks. The visual analogue scale(VAS) and neuropathic pain symptom inventory (NPSI) were evaluated. The response rate (proportion of subjects with at least a 30% to 50%reduction in visual analogue scale) was evaluated as the primary endpoint. ResultsThe response rate of the pregabalin group(36.4%) was significantly higher than that of the control group(9.1%)(χ2=4.98, P<0.05). Although hospital anxiety and depression level, clinical global impression of change, and clinical global impression of change (CGIC) did not differ significantly between pregabalin group and control group(P>0.05), improvements in neuropathic pain symptom inventory(NPSI), patient global impression of change(PGIC) and the sleep interference score(t=-6.62,-5.65,-6.16,P<0.05)suggested some utility in the management of radiation-induced brachial plexus. Conclusions Pregabalin treatment combined with conventional treatment exerts efficacy on patients with painful radiation-induced brachial plexus and patients are well tolerated. |
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