| Shao Shuai,Qu Gonglin,Tian Mei,et al.Protective effect of Sijunzi Tang on mouse immune damage and bone marrow damage caused by ionizing radiation[J].Chinese Journal of Radiological Medicine and Protection,2015,35(11):815-818 |
| Protective effect of Sijunzi Tang on mouse immune damage and bone marrow damage caused by ionizing radiation |
| Received:April 15, 2015 |
| DOI：10.3760/cma.j.issn.0254-5098.2015.11.004 |
| KeyWords:Sijunzi Tang Ionizing radiation Spleen Apoptosis Micronucleus |
| FundProject:"十二五"国家科技支撑计划项目(2013BAK03B05) |
| Author Name | Affiliation | E-mail | | Shao Shuai | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Centre for Disease Control and Prevention, Beijing 100088, China | | | Qu Gonglin | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Centre for Disease Control and Prevention, Beijing 100088, China | | | Tian Mei | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Centre for Disease Control and Prevention, Beijing 100088, China | | | Li Chen | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Centre for Disease Control and Prevention, Beijing 100088, China | | | Tu Xumin | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Centre for Disease Control and Prevention, Beijing 100088, China | | | Fan Li | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Centre for Disease Control and Prevention, Beijing 100088, China | | | Wang Chunyan | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Centre for Disease Control and Prevention, Beijing 100088, China | | | Qi Xuesong | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Centre for Disease Control and Prevention, Beijing 100088, China | | | Gou Qiao | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Centre for Disease Control and Prevention, Beijing 100088, China | | | Su Xu | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Centre for Disease Control and Prevention, Beijing 100088, China | suxu@nirp.cn |
|
| Hits: 3328 |
| Download times: 2808 |
| Abstract:: |
| Objective To investigate the protective effect of Sijunzi Tang on immune system damage and bone marrow damage in mice caused by ionizing radiation.Methods Eighty BALB/c mice aged 6–8 weeks were randomly by random number table method divided into normal control group, radiation group, and the other three groups of Sijunzi Tang at different dosages of 0.75, 2.25 and 6.75 g/kg, respectively. Radiation-damaged mouse model was single-irradiated by 3.5 Gy 60Co γ-rays. The spleen index, apoptosis of spleen cells, and the micronucleus rate of polychromatic erythrocyte were detected. Results At 7 d after irradiation, decrement of mouse spleen index were inhibited(t=-3.282,-6.386,-3.901, P<0.05) by all three dosages of Sijunzi Tang. Sijunzi Tang at the dosage of 2.25 g/kg reduced the early apoptosis of spleen cells at 3 d after irradiation(t=4.143, P<0.05) as well as late apoptosis of spleen cells at 7 d after irradiation(t=2.413, P<0.05). The micronucleus frequency of polychromatic erythrocyte was reduced by Sijunzi Tang dose-dependently(t=2.914,3.285,8.000, P<0.05). Conclusions Sijunzi Tang could alleviate the damage caused by ionizing radiation and improve mouse immune and hematopoietic function through increasing spleen index, reducing spleen cells apoptosis and micronucleus frequency of polychromatic erythrocyte. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
