| Zhang Yu,Qu Song,Li Ling,et al.Acute xerostomia and dosmimetric study in nasopharyngeal carcinoma patients[J].Chinese Journal of Radiological Medicine and Protection,2015,35(10):745-750 |
| Acute xerostomia and dosmimetric study in nasopharyngeal carcinoma patients |
| Received:March 04, 2015 |
| DOI：10.3760/cma.j.issn.0254-5098.2015.10.006 |
| KeyWords:Xerostomia Radiotherapy Salivary gland Nasopharyngeal carcinoma |
| FundProject:广西自然科学基金(桂科基0575090);广西医疗卫生重点科研项目(厅重200969);广西医疗卫生适宜技术研究与开发项目(S201417-04)。 |
| Author Name | Affiliation | E-mail | | Zhang Yu | Department of Radiation Oncology, Affiliated Cancer Hospital, Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning 530021, China | | | Qu Song | Department of Radiation Oncology, Affiliated Cancer Hospital, Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning 530021, China | | | Li Ling | Department of Radiation Oncology, Affiliated Cancer Hospital, Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning 530021, China | | | Zhao Wei | Department of Radiation Oncology, Affiliated Cancer Hospital, Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning 530021, China | | | Pei Su | Department of Radiation Oncology, Affiliated Cancer Hospital, Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning 530021, China | | | Chen Xiaoqian | Department of Radiation Oncology, Affiliated Cancer Hospital, Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning 530021, China | | | Liang Zhongguo | Department of Radiation Oncology, Affiliated Cancer Hospital, Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning 530021, China | | | Liang Zhenqiang | Department of Radiation Oncology, Affiliated Cancer Hospital, Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning 530021, China | | | Zhu Xiaodong | Department of Radiation Oncology, Affiliated Cancer Hospital, Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning 530021, China | zhuxdonggxmu@126.com |
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| Abstract:: |
| Objective To evaluate the relationship between radiation-induced acute xerostomia and the dosimetric factor changes of the parotid and submandibular glands. Methods A total of 109 nasopharyngeal carcinoma (NPC) patients who underwent IMRT were included. They were divided into two groups according to the severity of xerostomia: severe(52) and non-severe(57) mucositis groups. Several clinical factors including age, and chemotherapy were analyzed by chi-square test. The delivered doses as well as the volumes of the parotid and submandibular were also collected. The t-test was used to compare the differences between the two groups. The dosimetric factors(V15-V50)of the parotid glands were analyzed by Binary Logistic regression (Forward-conditional method). Results The incidence of severe acute xerostomia was 47.7%(52/109). There was no statistical difference between severe acute xerostomia and several clinical factors, which included age,mucositis and chemotherapy. The mean radiation doses of the glands between the severe and non-severe xerostomia group were statistically significant(t=-6.179,-6.055,-2.293,P<0.05). Logistic regression of the parotid gland showed that V34 was an independent indicating factor of severe acute xerostomia. When using V34=49% as a cut-off to predict severe xerostomia, the sensitivity and specificity were 71.2% and 75.4%, respectively(OR=1.231, P<0.05,95%CI:1.116-1.357). Conclusions The study evaluated the delivered doses of the parotid and submandibular glands and their relationship with acute xerostomia.V34 was a valuable indicator for predicting severe acute xerostomia. |
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