| Ding Xiang,Yu Shuhui,Long Qing,Xia Qun,Ai Yiqin,Li Wenhui,Cui Jianguo.Acute adverse effects of radiotherapy on HIV-positive patients with malignancy[J].Chinese Journal of Radiological Medicine and Protection,2015,35(9):687-689 |
| Acute adverse effects of radiotherapy on HIV-positive patients with malignancy |
| Received:January 29, 2015 |
| DOI：10.3760/cma.j.issn.0254-5098.2015.09.011 |
| KeyWords:Malignancy Radiotherapy Human immunodeficiency virus Acute adverse effect |
| FundProject: |
| Author Name | Affiliation | E-mail | | Ding Xiang | Department of Radiation Therapy, Yunnan Tumor Hospital, Kunming 650118, China | | | Yu Shuhui | Department of Radiation Therapy, Yunnan Tumor Hospital, Kunming 650118, China | | | Long Qing | Department of Radiation Therapy, Yunnan Tumor Hospital, Kunming 650118, China | | | Xia Qun | Department of Radiation Therapy, Yunnan Tumor Hospital, Kunming 650118, China | | | Ai Yiqin | Department of Radiation Therapy, Yunnan Tumor Hospital, Kunming 650118, China | | | Li Wenhui | Department of Radiation Therapy, Yunnan Tumor Hospital, Kunming 650118, China | | | Cui Jianguo | Department of Radiation Therapy, Yunnan Tumor Hospital, Kunming 650118, China | ccjjgg@163.com |
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| Abstract:: |
| Objective To observe and evaluate acute toxicities in a series of human immunodeficiency virus (HIV)-positive cancer patients receiving radiation therapy. Methods The study retrospectively reviewed the acute radiation reaction of radiation therapy of 14 HIV seropositive patients diagnosed with carcinoma between Feb 2008 and Dec 2013 at the Yunnan Tumor Hospital during the radiotherapy period and 1 month following treatment. Acute adverse effects were classified according to the site of radiation therapy and analyzed using the Common Terminology Criteria for Adverse Events (CTCAE) version 3.0. Results Seven patients experienced interruptions or delays in treatment, and 2 stopped treatment entirely. The most common acute adverse effects were skin reactions and mucous membrane reactions, including dermatitis, stomatitis or diarrhea. Eight patients had grade 3 acute adverse effects, including 6 patients with grade 3 skin reactions and 2 patients with grade 3 mucosa reactions. Conclusions Radiotherapy is an effective treatment for HIV positive patients with tumors, however it frequently induced severe acute radiation responses. |
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