| Sun Tao,Lin Xiutong,Tang Hui,Yin Yong,Liu Tonghai,Zhang Guifang,Zhu Jian.Application of beam angle optimization for multiple intracranial metastases[J].Chinese Journal of Radiological Medicine and Protection,2015,35(9):674-678 |
| Application of beam angle optimization for multiple intracranial metastases |
| Received:March 18, 2015 |
| DOI：10.3760/cma.j.issn.0254-5098.2015.09.008 |
| KeyWords:Multiple intracranial metastases Intensity-modulated radiotherapy Beam angle optimization Dosimetry |
| FundProject: |
| Author Name | Affiliation | E-mail | | Sun Tao | Department of Radiation Oncology Physicist, Shandong Cancer Hospital, Shandong Provincial Key Laboratory of Radiation Oncology, Jinan 250117, China | | | Lin Xiutong | Department of Radiation Oncology Physicist, Shandong Cancer Hospital, Shandong Provincial Key Laboratory of Radiation Oncology, Jinan 250117, China | | | Tang Hui | 济南空军选拔中心 | | | Yin Yong | Department of Radiation Oncology Physicist, Shandong Cancer Hospital, Shandong Provincial Key Laboratory of Radiation Oncology, Jinan 250117, China | | | Liu Tonghai | Department of Radiation Oncology Physicist, Shandong Cancer Hospital, Shandong Provincial Key Laboratory of Radiation Oncology, Jinan 250117, China | lthsdu@163.com | | Zhang Guifang | Department of Radiation Oncology Physicist, Shandong Cancer Hospital, Shandong Provincial Key Laboratory of Radiation Oncology, Jinan 250117, China | | | Zhu Jian | Department of Radiation Oncology Physicist, Shandong Cancer Hospital, Shandong Provincial Key Laboratory of Radiation Oncology, Jinan 250117, China | |
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| Abstract:: |
| Objective To study the dosimetric impact of different angle fields in intensity-modulated radiotherapy (IMRT) and the feasibility of beam angle optimization (BAO) for multiple intracranial metastases. Methods In total, 11 patients with multiple intracranial metastases were included in these analyses. Two treatment techniques were designed for each patient: the 7 equal spaced fields (BAF group) IMRT, and 7 fields by beam angle optimization (BAO group) IMRT. The dose distribution in the target, the dose to the organs at risk and normal brain tissues, and total MU in two groups were compared to explore the dosimetric differences. Results In comparison to the BAF group, the BAO group reduced the maximum dose to left and right lenses by an average of 45%, 37% (t=-5.707, -4.438, P<0.05);the mean dose to the left and right eyes were reduced by an average of 42.6%, 44.5% (t=-4.380, -5.638, P<0.05);the maximum dose to the right eyes were reduced by an average of 32.5% (t=-2.518, P<0.05). The maximum dose of the right optic nerve and the mean dose of normal brain tissue were reduced by an average of 23% and 3% (t=-3.105, -3.437, P<0.05), respectively. For the target dose, conformity and homogeneity in PTV, no statistical differences were observed between the two groups (P>0.05). The BAO group reduced the maximum dose of the brainstem and the optic chiasm, as well as the number of MU, however, the differences were not statistically significant (P>0.05). Conclusions In comparison to the BAF group, the BAO group shows a similar target dose and reduces the dose for the organs at risk. For multiple intracranial metastases, IMRT protocols with BAO are feasible and beneficial. |
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