| Shen Guanzhu,Deng Xiaowu,Wu Shaoxiong,et al.Application of risk category system to evaluate the treatment outcome of locoregionally advanced nasopharyngeal carcinoma treated by intensity-modulated radiation therapy alone[J].Chinese Journal of Radiological Medicine and Protection,2015,35(7):518-521 |
| Application of risk category system to evaluate the treatment outcome of locoregionally advanced nasopharyngeal carcinoma treated by intensity-modulated radiation therapy alone |
| Received:March 04, 2015 |
| DOI：10.3760/cma.j.issn.0254-5098.2015.07.009 |
| KeyWords:Intensity-modulated radiation therapy Nasopharyngeal carcinoma Risk category |
| FundProject: |
| Author Name | Affiliation | E-mail | | Shen Guanzhu | Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou 510060, China | | | Deng Xiaowu | Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou 510060, China | | | Wu Shaoxiong | Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou 510060, China | | | Xiao Weiwei | Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou 510060, China | | | Han Fei | Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou 510060, China | | | Li Anchuan | Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou 510060, China | | | Zhao Chong | Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou 510060, China | zhaochong@sysucc.org.cn |
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| Abstract:: |
| Objective To explore the feasibility of employing a risk category system in evaluating the treatment outcome of locoregionally advanced nasopharyngeal carcinoma (NPC) treated by intensity-modulated radiation therapy (IMRT) alone, and offering evidence for relevant perspective studies. Methods Totally 185 locoregionally advanced NPC patients were divided into high-risk and low-risk groups for evaluation and comparison. The patients who met at least one of the following criteria were defined as high-risk group and others as low-risk group: GTVnx>30 cm3; Clinical stage T4N2M0; multiple neck node metastases with 1 node size >4 cm, and N3 with any T stage. Results With a median follow up of 110.9 months (6.7-152.4 months), the 5-year overall survival, locoregional relapse-free survival, distant metastasis-free survival for thehigh-risk group vs. the low-risk group were 61.0% vs.90.5%(χ2=30.298,P<0.05), 78.3% vs. 91.5%(χ2=6.352,P<0.05)and 71.6% vs. 92.0%(χ2=16.346,P<0.05). Conclusions As a simple and practicable method, the risk category system is helpful for discriminating locoregionally advanced nasopharyngeal carcinoma with different risk-group of treatment failure and in further perspective clinical research. |
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