| Li Zhuoling,Jin Feng,Wu Weili,et al.A prospective and randomized study of induction and concurrent chrono-chemotherapy combined with intensity modulated radiotherapy in nasopharyngeal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2015,35(7):505-509 |
| A prospective and randomized study of induction and concurrent chrono-chemotherapy combined with intensity modulated radiotherapy in nasopharyngeal carcinoma |
| Received:January 14, 2015 |
| DOI：10.3760/cma.j.issn.0254-5098.2015.07.006 |
| KeyWords:Nasopharyngeal carcinoma Chrono-chemotherapy Intensity modulated radiotherapy Concurrence chemoradiotherapy Adverse reaction |
| FundProject:贵州省科技厅基金项目(黔科合LG字[2012]065号);贵阳市社会发展与民生科技计划项目(筑科合同[2013103]29号) |
| Author Name | Affiliation | E-mail | | Li Zhuoling | Department of Head and Neck Oncology, Guizhou Cancer Hospital, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China | | | Jin Feng | Department of Head and Neck Oncology, Guizhou Cancer Hospital, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China | jinf8865@yeah.net | | Wu Weili | Department of Head and Neck Oncology, Guizhou Cancer Hospital, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China | | | Li Yuanyuan | Department of Head and Neck Oncology, Guizhou Cancer Hospital, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China | | | Long Jinhua | Department of Head and Neck Oncology, Guizhou Cancer Hospital, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China | | | Gong Xiuyun | Department of Head and Neck Oncology, Guizhou Cancer Hospital, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China | | | Chen Xiaoxiao | Department of Head and Neck Oncology, Guizhou Cancer Hospital, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China | | | Mao Zhenhua | Department of Head and Neck Oncology, Guizhou Cancer Hospital, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China | |
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| Abstract:: |
| Objective To evaluate the adverse reactions, immune function and clinical response of induction chemotherapy followed by concurrent chrono-chemotherapy or conventional chemotherapy with intensity modulated radiotherapy in locally advanced nasopharyngeal carcinoma. Methods Sixty patients with locally advanced nasopharyngeal carcinoma were randomly distributed into two groups. Experimental group was induction chemotherapy followed by concurrent chrono-chemotherapy with intensity modulated radiotherapy. Control group was induction chemotherapy followed by conventional chemotherapy with intensity modulated radiotherapy. Induction chemotherapy with docetaxel and cisplatin and 5-fluorouracil of 2 cycles was used in both two groups. Two groups concurrent chemotherapy with cisplatin in different ways. Experimental group was chrono-chemotherapy, and control group was conventional chemotherapy. Two groups evaluate the adverse reactions and immune function and clinical response. Results Nausea(Z=2.50, P<0.05) and vomiting(Z=3.31, P<0.05) in experimental group was lighter than those in control group during concurrence chemoradiotherapy. CD4+/CD8+(t=3.34, P<0.05) in experimental group was higher than control group after concurrence chemoradiotherapy. The curative effect of two groups was no statistically significant difference(P>0.05) after induction chemotherapy followed by concurrent chemoradiotherapy. Conclusions The concurrent chrono-chemotherapy can reduce adverse reactions of nausea and vomiting, and improve immune function without reducing the curative effect. It is possible to be a more reasonable treatment of nasopharyngeal carcinoma. |
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