Li Zhi,Jiang Shan,Yang Zhiyong,et al.Monte Carlo simulation and experimental investigation of 125I interseed dose attenuation[J].Chinese Journal of Radiological Medicine and Protection,2015,35(5):389-392
Monte Carlo simulation and experimental investigation of 125I interseed dose attenuation
Received:September 03, 2014  
DOI:10.3760/cma.j.issn.0254-5098.2015.05.019
KeyWords:Brachytherapy  125I seed  dose attenuation  Geant 4  Monte Carlo
FundProject:国家自然科学基金(51175373);天津市科技支撑重大项目(12ZCDZSY10600)
Author NameAffiliationE-mail
Li Zhi 300072 天津大学机械工程学院  
Jiang Shan 300072 天津大学机械工程学院 shanjiang@tju.edu.cn 
Yang Zhiyong 300072 天津大学机械工程学院  
Bai Hongsheng 天津赛德生物制药有限公司  
Zhang Xingfu 天津赛德生物制药有限公司  
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Abstract::
      Objective To investigate the interseed dose attenuation for multiple 125I seeds. Methods Monte Carlo simulation was done by Geant 4 to investigate the dose distribution of single seed and multiple seeds. The results were compared with the dose calculation method from TG43-U1 and examined by experiments. Results The difference of single seed dose distribution between Monte Carlo method and line source model was ± 3%. The difference between Monte Carlo method and experiment result was ± 5%. The interseed dose attenuation of multiple seeds at the interesting points was 3.8% to 13.2% and the average interseed dose attenuation was 7.2%. The difference of experiment result and Monte Carlo result was less than 6%. Conclusions The interseed attenuation is about 7% and the maximum value may be larger than 13% for multiple seeds. The interseed dose attenuation may be larger in tissue. So it is not accurate to calculate the dose distribution by using TG43-U1.
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