| Zhong Sheng,Wu Qingquan,Wang Wanwei,Tao Guangzhou,Peng Jin,Zhu Weiguo.Predictive value of imaging evaluation in stage Ⅱ/Ⅲ esophageal carcinoma patients treated with preoperative chemoradiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2015,35(4):270-273 |
| Predictive value of imaging evaluation in stage Ⅱ/Ⅲ esophageal carcinoma patients treated with preoperative chemoradiotherapy |
| Received:August 06, 2014 |
| DOI：10.3760/cma.j.issn.0254-5098.2015.04.008 |
| KeyWords:Esophageal carcinoma Preoperative chemoradiotherapy Complete response Imaging Prognosis |
| FundProject: |
| Author Name | Affiliation | E-mail | | Zhong Sheng | Department of Thoracic Surgery, Huaian First People's Hospital, Nanjing Medical University, Huaian 223300, China | | | Wu Qingquan | Department of Thoracic Surgery, Huaian First People's Hospital, Nanjing Medical University, Huaian 223300, China | | | Wang Wanwei | 223300 淮安, 南京医科大学附属淮安第一医院放疗科 | | | Tao Guangzhou | 223300 淮安, 南京医科大学附属淮安第一医院放疗科 | | | Peng Jin | 223300 淮安, 南京医科大学附属淮安第一医院放疗科 | | | Zhu Weiguo | 223300 淮安, 南京医科大学附属淮安第一医院放疗科 | jshazwg@126.com |
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| Abstract:: |
| Objective Retrospectively analyzed the predictive value of imaging evaluation in stage Ⅱ/Ⅲ esophageal carcinoma patients treated with preoperative chemoradiotherapy. Methods A total of 145 stage Ⅱ/Ⅲ esophageal carcinoma pantients were enrolled. We analyzed the overall survival rates of the patients with pathological complete response (pCR) and those without (NpCR), X-film complete response (xCR) and those without (NxCR), RECIST complete response (rCR) and those without (NrCR). And we used Cox model for multivariate analysis. Results The rates of pCR, xCR and rCR were 33.8%, 42.8% and 38.6% for all patients, respectively. The 1-,3- 5-year overall survival rates were 87.8%, 79.6%, 61.2% for pCR patients and 75%, 40.6%, 24.0% for NpCR patients(χ2=20.215,P<0.05), respectively; The 1-,3- 5-year overall survival rates were 80.6%, 66.1%, 51.6% for xCR patients and 75%, 44.6%, 25.3% for NxCR patients(χ2=8.895,P<0.05), respectively; The 1-,3- 5-year overall survival rates were 83.9%, 69.6%, 53.6% for rCR patients and 76.4%, 46.1%, 25.8% for NxCR patients(χ2=10.862,P<0.05), respectively. Multivariate survival analysis using Cox regression model showed that pCR was a positive independent prognostic factor (HR=0.333, 95%CI:0.200-0.554, P<0.05). Conclusions Short-term imaging evaluation could effectively predict the prognosis of stageⅡ/Ⅲ esophageal carcinoma patients treated with preoperative chemoradiotherapy. And pCR was a positive independent prognostic factor. |
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