| Jin Jin,Bai Jiali,Long Wei,Shen Xiu,Xu Wenqing,Zhou Zewei.The protective effect of pyrrolidine dithiocarbamate on acute radiation injury in mice[J].Chinese Journal of Radiological Medicine and Protection,2015,35(4):257-260 |
| The protective effect of pyrrolidine dithiocarbamate on acute radiation injury in mice |
| Received:September 05, 2014 |
| DOI：10.3760/cma.j.issn.0254-5098.2015.04.005 |
| KeyWords:Pyrrolidine dithiocarbamate γ-rays ICR mice Radiation injury |
| FundProject: |
| Author Name | Affiliation | E-mail | | Jin Jin | Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China | | | Bai Jiali | 山西省长治市妇幼保健院 | | | Long Wei | Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China | | | Shen Xiu | Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China | | | Xu Wenqing | Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China | | | Zhou Zewei | Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China | zhouzewei@irm-cams.ac.cn |
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| Abstract:: |
| Objective To study the protective effect of pyrrolidine dithiocarbamate (PDTC) on acute irradiated mice. Methods The 6-8 weeks old male ICR mice were randomly divided into five groups: irradiation alone group (IR), positive control group (amifostine WR-2721 250 mg/kg) and PDTC of 30, 60 and 90 mg/kg dose groups. Each group had 10 mice and the drug was given at 0.5 h before whole body irradiation. At 30 d post-irradiation of 7.5 Gy 137Cs γ-rays, the mice survival were observed. At 8 d post-irradiation of 5.0 Gy 137Cs γ-rays, the peripheral blood, hematopoietic system and organ indexes were observed to evaluate the radiation protective effect of PDTC. Results PDTC increased the 30-day survival rates and 60 mg/kg dose had the most obvious effect by increase the survival to 60%(6/10). The survivals of irradiation alone group and the amifostine positive control group was 10%(1/10) and 70%(7/10), respectively. Compared with the irradiation alone group, 60 mg/kg PDTC group had the significant difference in spleen index, WBC, HGB, PLT, bone marrow nucleated cells and colony forming unit of spleen(t=2.354, 4.793, 2.342, 6.542, 2.649, 3.982, P<0.05). Conclusions PDTC is effective in radiation protection with an optimum dose of 60 mg/kg. |
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