| Liu Chunxu,Tian Mei,Pan Yan,et al.Expression of miRNAs in peripheral blood plasma of the residents surrounding hot springs with radon[J].Chinese Journal of Radiological Medicine and Protection,2015,35(3):187-190 |
| Expression of miRNAs in peripheral blood plasma of the residents surrounding hot springs with radon |
| Received:July 17, 2014 |
| DOI：10.3760/cma.j.issn.0254-5098.2015.03.006 |
| KeyWords:Hot springs with radon Plasma miRNAs |
| FundProject:国家自然科学基金(31100606) |
| Author Name | Affiliation | E-mail | | Liu Chunxu | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Tian Mei | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Pan Yan | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Gao Gang | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Liu Jianxiang | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | jxliu@163.com |
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| Abstract:: |
| Objective To investigate the expressions of miR-16, miR-106b, miR-449a, miR-34a and let-7g in peripheral blood plasma of the residents surrounding hot springs with radon in Hebei province.Methods A total of 41 randomly selected residents surrounding hot springs with radon were considered as the radon group, and 46 residents with same living habit but without contact with hot springs were considered as control. The miRNAs in the peripheral blood plasma of these two groups were detected with qRT-PCR.Results The levels of miR-16, miR-106b, miR-449a and let-7g in the radon group were significantly higher than those in control group (Z=-2.278, -3.835, -2.719, -2.721,P<0.05). Alterations of these miRNAs were associated with radon exposure (t=2.154, 3.711, 2.319, 2.015,P<0.05) but had no relationship with age, sex, smoking and drinking factors. No significant difference was observed in the plasma levels of miR-34a between the two groups.Conclusions miR-16, miR-106b, miR-449a and let-7g could be applied as potential biomarkers for radon exposure. |
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