| Wang Zixia,Meng Xiangxi,Zhang Zhenyao,et al.Automated 18F-FDG drug delivery system: Reducing occupational radiation exposure and improving injection accuracy[J].Chinese Journal of Radiological Medicine and Protection,2026,46(4):407-413 |
| Automated 18F-FDG drug delivery system: Reducing occupational radiation exposure and improving injection accuracy |
| Received:April 09, 2025 |
| DOI：10.3760/cma.j.cn112271-20250409-00131 |
| KeyWords:Automated drug delivery system|Radiopharmaceutical|Radiation protection|18F-FDG |
| FundProject:国家自然科学基金(82472015,12505390);北京市医管局登峰人才计划(DFL20241103);北京市卫健委研究型病房卓越临床研究计划(BRWEP2024W032150102);国家重点研发计划(2022YFC2409405) |
| Author Name | Affiliation | E-mail | | Wang Zixia | Department of Nuclear Medicine, Beijing Institute for Cancer Research, Beijing Cancer Hospital, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals, Beijing Key Laboratory of Research, Investigation and Evaluation of Radiopharmaceuticals, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Beijing 100142, China | | | Meng Xiangxi | Department of Nuclear Medicine, Beijing Institute for Cancer Research, Beijing Cancer Hospital, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals, Beijing Key Laboratory of Research, Investigation and Evaluation of Radiopharmaceuticals, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Beijing 100142, China | | | Zhang Zhenyao | Department of Nuclear Medicine, Beijing Institute for Cancer Research, Beijing Cancer Hospital, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals, Beijing Key Laboratory of Research, Investigation and Evaluation of Radiopharmaceuticals, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Beijing 100142, China | | | Liu Shiwei | Department of Nuclear Medicine, Beijing Institute for Cancer Research, Beijing Cancer Hospital, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals, Beijing Key Laboratory of Research, Investigation and Evaluation of Radiopharmaceuticals, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Beijing 100142, China | | | Yang Zhi | Department of Nuclear Medicine, Beijing Institute for Cancer Research, Beijing Cancer Hospital, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals, Beijing Key Laboratory of Research, Investigation and Evaluation of Radiopharmaceuticals, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Beijing 100142, China | | | Li Nan | Department of Nuclear Medicine, Beijing Institute for Cancer Research, Beijing Cancer Hospital, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals, Beijing Key Laboratory of Research, Investigation and Evaluation of Radiopharmaceuticals, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Beijing 100142, China | rainbow6283@sina.com |
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| Abstract:: |
| Objective To compare manual injection with an automated drug delivery system for 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) administration, focusing on injection accuracy, radiation exposure levels, and the surface contamination of operational areas, and to evaluate the clinical applicability of the automated injection system. Methods A total of 504 patients who underwent positron emission tomography/computed tomography (PET/CT) and 18F-FDG administration at the Department of Nuclear Medicine, Peking University Cancer Hospital & Institute between December 2024 and January 2025 were enrolled in this study. These patients were divided into two groups: the manual injection group (n = 249) and the automated delivery group (n = 255). The dispensed and injected doses of both groups were recorded. During the injection, the peak ambient dose equivalent rates (ADERs) at the nurse's arm (10 cm from the needle) and torso (anterior chest) were monitored using portable radiation monitoring instruments. Following the injection, the peak ADERs on the injection bench, gloves, and 1 cm above the floor were measured and recorded. Results The automated drug delivery system outperformed manual injection significantly in terms of injection accuracy, radiation exposure reduction, and contamination control in the operational areas, with statistically significant inter-group differences (Z = -19.44 to -3.16, P < 0.05) Specifically, the manual injection and automated delivery groups showed injected activity deviation rates of 8.01% and 0.83%, respectively. During injection, both groups exhibited average peak ADERs at the nurse's arm of 2 415 and 51.09 μSv/h and average peak ADERs at the torso of 1.49 and 0.14 μSv/h, respectively. After injection, both groups showed maximum ADERs on the bench surface of 16.11 and 0.39 μSv/h and maximum ADERs on the glove surface of 15.04 and 0.15 μSv/h, respectively. Meanwhile, for the two groups, the maximum ADERs 1 cm above the floor fell at the background levels. No surface contamination was detected in the automated delivery group. In contrast, contamination occurred at the bench and glove surfaces in the manual group, with incidences of 7% and 3%, respectively. Conclusions The automated 18F-FDG drug delivery system outperforms in terms of injection accuracy, environmental contamination control, and radiation protection. Therefore, this system is expected to enhance the safety of clinical operations. |
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