| Liu Lou,Fu Yi,Li Shuyue,et al.Clinical applications and advances of online adaptive radiotherapy in cervical cancer treatment[J].Chinese Journal of Radiological Medicine and Protection,2026,46(3):315-321 |
| Clinical applications and advances of online adaptive radiotherapy in cervical cancer treatment |
| Received:April 10, 2025 |
| DOI：10.3760/cma.j.cn112271-20250410-00133 |
| KeyWords:Adaptive radiotherapy Cervical cancer Artificial intelligence |
| FundProject:国家自然科学基金(81602792);江苏省卫生健康委员会面上项目(M2024004);江苏省高等学校基础科学(自然科学)研究面上项目(23KJB310023);江苏省妇幼保健科研项目(F202210);江苏省医学重点学科(ZDXK202235);放射医学与辐射防护国家重点实验室资助项目(GZK1202101);苏州市科技项目(SLT201920);苏州大学附属第一医院临床诊疗技术创新项目青年特色技术项目(2100201) |
| Author Name | Affiliation | E-mail | | Liu Lou | Department of Radiation Oncology, First Affiliated Hospital of Soochow University, Suzhou 215006, China | | | Fu Yi | Department of Radiation Oncology, First Affiliated Hospital of Soochow University, Suzhou 215006, China | | | Li Shuyue | Department of Radiation Oncology, First Affiliated Hospital of Soochow University, Suzhou 215006, China | | | Chen Jie | Department of Radiation Oncology, First Affiliated Hospital of Soochow University, Suzhou 215006, China | | | Xu Chao | Department of Radiation Oncology, First Affiliated Hospital of Soochow University, Suzhou 215006, China | | | Zhou Juying | Department of Radiation Oncology, First Affiliated Hospital of Soochow University, Suzhou 215006, China | | | Ma Chenying | Department of Radiation Oncology, First Affiliated Hospital of Soochow University, Suzhou 215006, China | machenying@suda.edu.cn |
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| Abstract:: |
| Since the beginning of the 21st century, radiotherapy has evolved from two-dimensional techniques to image-guided radiotherapy, significantly improving the accuracy of irradiation. However, due to variations in the filling status of the cervix and its surrounding organs, substantial inter-fraction displacement of the tumor can occur. Conventional radiotherapy addresses this challenge by incorporating a sufficient safety margin around the clinical target volume (CTV), yet the risk of CTV underdosing remains. To address this issue, adaptive radiotherapy (ART) has been developed, with the core concept of adjusting the treatment plan in real-time according to the dynamic changes of the anatomical structure during the course of radiotherapy. Online ART enables "plan adaptation before irradiation" by acquiring daily patient images, automatically contouring target volumes and organs at risk, optimizing the treatment plan, and delivering the adapted plan in each session. This approach reduces the required CTV margins and minimizes radiation exposure to normal tissues, and is considered an important direction for cervical cancer radiotherapy. This review focuses on the current applications of online ART in cervical cancer, examines key technologies and recent advances in its development, and discusses future development directions. |
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