| Guan Ziyi,Ma Liping,Gao Ling.Advances in research on effects of radiation on cell stemness transition and their mechanisms[J].Chinese Journal of Radiological Medicine and Protection,2026,46(2):205-212 |
| Advances in research on effects of radiation on cell stemness transition and their mechanisms |
| Received:July 28, 2025 |
| DOI：10.3760/cma.j.cn112271-20250728-00269 |
| KeyWords:Ionizing radiation Stemness-related gene Cell stemness transition |
| FundProject: |
| Author Name | Affiliation | E-mail | | Guan Ziyi | China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute of Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Ma Liping | China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute of Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Gao Ling | China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute of Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | gaoling@nirp.chinacdc.cn |
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| Abstract:: |
| Ionizing radiation can induce cell stemness transition through multiple mechanisms, such as DNA damage and repair, activation of stemness-related signaling pathways, and epigenetic modifications. Such stemness transition can further affect cell injury and tumorigenesis. Specifically, stemness-related genes, such as Wnt, Notch, and Hedgehog, participate in radiation response, while transcription factors, including Nanog, Oct4, Sox2, and LGR5, are directly involved in the regulation of the cell stemness transition. This study reviews the biological characteristics of cell stemness transition, along with advances in research on the role of stemness-related genes in radiation-induced cell stemness transition. The purpose is to provide theoretical support and bases for both research on stemness transition and the targeted intervention of stemness-related genes for radiation-induced injury. |
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