| Zhu Hongyu,Hu Ankang,Lai Youfang,et al.Research advances in microscopic Monte Carlo simulations of FLASH irradiation[J].Chinese Journal of Radiological Medicine and Protection,2025,45(11):1157-1164 |
| Research advances in microscopic Monte Carlo simulations of FLASH irradiation |
| Received:July 08, 2025 |
| DOI：10.3760/cma.j.cn112271-20250708-00235 |
| KeyWords:FLASH irradiation Monte Carlo simulation Radiobiological effect |
| FundProject:国家重点研发计划项目(2022YFC2402304);国家自然科学基金(12305410,12405359);广州市科技局基础与应用基础研究专题(优秀博士"续航"项目,2025A04J2004) |
| Author Name | Affiliation | E-mail | | Zhu Hongyu | Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University & Chinese Academy of Sciences Ion Medical Technology Co., Ltd., Guangzhou 510060, China | | | Hu Ankang | Department of Engineering Physics, Tsinghua University, Beijing 100084, China | | | Lai Youfang | Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, MD 21287, USA | | | Yang Yuchen | Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University & Chinese Academy of Sciences Ion Medical Technology Co., Ltd., Guangzhou 510060, China | | | Deng Xiaowu | Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University & Chinese Academy of Sciences Ion Medical Technology Co., Ltd., Guangzhou 510060, China | dengxw@sysucc.org.cn |
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| Abstract:: |
| FLASH irradiation (FLASH-IR) is one of the cutting-edge research directions in the field of tumor radiotherapy. Previous studies have demonstrated that FLASH-IR can effectively eradicate tumors while significantly reducing damage to normal tissues, exhibiting unique biological effects characterized by high efficiency and low toxicity. Monte Carlo simulation at the microscopic scale is a critical method for studying radiobiological effects and has been widely applied in conventional radiotherapy research. In recent years, its application in microscopic reaction analysis and mechanistic exploration of FLASH-IR has grown rapidly. This article systematically reviews the latest advances and key challenges in microscopic Monte Carlo simulation studies of FLASH-IR, aiming to provide theoretical insights and method ological guidance for future research. |
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