| Radiotherapy Equipment and Technology Branch of China Medical Equipment Association.Expert consensus on preclinical research into high-energy X-ray FLASH irradiation[J].Chinese Journal of Radiological Medicine and Protection,2025,45(11):1052-1060 |
| Expert consensus on preclinical research into high-energy X-ray FLASH irradiation |
| Received:July 07, 2025 |
| DOI：10.3760/cma.j.cn112271-20250707-00229 |
| KeyWords:High-energy X-ray FLASH irradiation Preclinical study Experimental procedure Expert consensus |
| FundProject:国家自然科学基金(U2330122);四川省科技计划项目(2024ZDZX0027) |
|
| Hits: 3941 |
| Download times: 681 |
| Abstract:: |
| FLASH radiotherapy is a technique involving the delivery of irradiation at ultra-high dose rates (≥ 40 Gy/s). Compared to conventional dose rate radiotherapy (CONV), this technique can significantly reduce radiation-induced injury to normal tissues and the duration of radiotherapy while maintaining equivalent tumor-killing capacities. High-energy X-ray FLASH irradiation (X-FLASH), a novel radiotherapy, has seen a surge in the number of preclinical studies in an effort to accelerate its clinical translation. However, there is a lack of consensus regarding standardized experimental procedures. This study aims to establish a standardized preclinical research framework for X-FLASH that covers the entire experimental workflow, including ionizing radiation dosimetry, in vitro cell irradiation experiments, and irradiation models of both healthy and tumor-bearing mice for in vitro irradiation experiments. The purpose is to provide reproducible preclinical procedures for elucidating mechanisms underlying the FLASH effect, validating device performance, and guiding future clinical studies. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
