| Zhou Ruixia,Li Shuang.Research progress of miRNAs in peripheral blood as biomarkers of ionizing radiation damage[J].Chinese Journal of Radiological Medicine and Protection,2025,45(9):920-924 |
| Research progress of miRNAs in peripheral blood as biomarkers of ionizing radiation damage |
| Received:November 25, 2024 |
| DOI：10.3760/cma.j.cn112271-20241125-00455 |
| KeyWords:miRNAs Radiation damage Biomarkers |
| FundProject:国家自然科学基金(82173464) |
| Author Name | Affiliation | | Zhou Ruixia | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 10088, China | | Li Shuang | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 10088, China |
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| Abstract:: |
| In the case of acute radiation-induced damage, rapidly and accurately assessing the exposure dose using biomarkers is crucial to medical treatment. In recent years, with the application of technologies such as metabolomics, immunomics, and genomics, more radiation biomarkers have emerged based on gene transcription markers and radiation metabolites. MicroRNAs (miRNAs), a type of molecular biomarkers, have demonstrated great potential in radiation damage assessment due to their simplicity of tests and high throughput. This review summarized the biological characteristics of miRNAs and advances in research on peripheral blood miRNAs as biomarkers of radiation-induced damage. |
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