| Wang Ping,Han Lin,Li Jie,et al.Feasibility of applying auxiliary analysis software to chromosomal aberration analysis of radiation workers[J].Chinese Journal of Radiological Medicine and Protection,2025,45(8):750-756 |
| Feasibility of applying auxiliary analysis software to chromosomal aberration analysis of radiation workers |
| Received:December 09, 2024 |
| DOI：10.3760/cma.j.cn112271-20241209-00469 |
| KeyWords:Radiation worker Chromosome aberration analysis Peripheral blood lymphocyte |
| FundProject:河南省医学科技攻关计划项目(LHGJ20230553);河南省医学科技攻关计划项目省部共建青年项目(SBGJ202403047) |
| Author Name | Affiliation | E-mail | | Wang Ping | Department of Toxicology, Third People's Hospital of Henan Province (Henan Occupational Disease Hospital), Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Han Lin | Department of Toxicology, Third People's Hospital of Henan Province (Henan Occupational Disease Hospital), Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Li Jie | Department of Toxicology, Third People's Hospital of Henan Province (Henan Occupational Disease Hospital), Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Du Shasha | Department of Toxicology, Third People's Hospital of Henan Province (Henan Occupational Disease Hospital), Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Zhang Yunfei | Department of Toxicology, Third People's Hospital of Henan Province (Henan Occupational Disease Hospital), Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Li Xiaohao | Department of Toxicology, Third People's Hospital of Henan Province (Henan Occupational Disease Hospital), Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Fang Siqi | Department of Toxicology, Third People's Hospital of Henan Province (Henan Occupational Disease Hospital), Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Gao Yu | Department of Toxicology, Third People's Hospital of Henan Province (Henan Occupational Disease Hospital), Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Niu Xianfei | Department of Toxicology, Third People's Hospital of Henan Province (Henan Occupational Disease Hospital), Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Lyu Yumin | Department of Toxicology, Third People's Hospital of Henan Province (Henan Occupational Disease Hospital), Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | lym636160@sina.com |
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| Abstract:: |
| Objective To explore the feasibility of the new auxiliary analysis software in chromosomal aberration analysis of radiation workers during occupational health examinations. Methods Health examination data of 2 469 radiation workers in Henan province were collected. Manual analysis of chromosomal aberrations in peripheral blood lymphocytes was conducted using the new auxiliary software and the Ikaros software. Then, the chromosomal aberrations detected using both software tools were compared. Results The new auxiliary software yielded a lower chromosomal aberration rate among radiation workers compared with the Ikaros software [(0.314 ± 0.014)% vs. (0.391 ± 0.022)%, χ2 = 9.24, P = 0.002]. Notably, the new auxiliary software yielded a significantly lower rate of acentric fragments (ace) [(0.136 ± 0.009)% vs. (0.209 ± 0.020)%, χ2= 17.76, P < 0.001]. However, no statistically significant differences were observed between the result of the two software tools in the rates of dicentrics plus rings (dic + r) and translocations (P > 0.05). According to the GBZ/T 248-2014 standard, the differences in abnormality rates of chromosomal aberrations between the two groups had no statistically significance (P > 0.05), with both groups showing an abnormality rate of 0 for ace. Furthermore, the new auxiliary software could double the detection efficiency. Among pre-service radiation workers of various occupations, the differences in the chromosomal aberrations detected using the two software tools exhibited statistical significance (χ2 = 10.26, P = 0.001). In contrast, the differences in the chromosomal aberrations among in-service and post-service radiation workers had no statistically different significance (P>0.05). The Poisson regression analysis result demonstrated that the rate of chromosomal aberrations excluding ace was affected by age (z = 2.73, P = 0.006), while gender, analysis method, service status, and occupation had no impact. Conclusions The two software tools yielded largely consistent result in detecting chromosomal aberrations induced by exposure to ionizing radiation. Notably, the new auxiliary software can significantly improve detection efficiency, indicating the feasibility of applying it to chromosomal aberration analysis among radiation workers. |
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