| Wu Xue,Chang De.Advances in lung-related bystander and abscopal effects induced by radiation[J].Chinese Journal of Radiological Medicine and Protection,2025,45(7):699-705 |
| Advances in lung-related bystander and abscopal effects induced by radiation |
| Received:July 18, 2024 |
| DOI：10.3760/cma.j.cn112271-20240718-00265 |
| KeyWords:Radiation-induced bystander effect Abscopal effect Thoracic radiotherapy |
| FundProject:国家"十四五"重点研发计划青年科学家项目(2021YFC2302300);人才工程项目(02-SWKJYCJJ21,2021-439,2022-QN07351,LZ2024-10);解放军总医院3+1创新人才工程(20230315);北京市科技新星计划交叉学科合作课题(20220484197) |
| Author Name | Affiliation | E-mail | | Wu Xue | Department of Respiratory and Critical Care Medicine, the Eighth Medical Center of Chinese PLA General Hospital, Beijing 100091, China
Department of Respiratory and Critical Care Medicine, Seventh Medical Center, Chinese PLA General Hospital, Beijing 100700, China
Graduate School of Chinese PLA General Hospital, Beijing 100853, China | | | Chang De | Department of Respiratory and Critical Care Medicine, the Eighth Medical Center of Chinese PLA General Hospital, Beijing 100091, China
Department of Respiratory and Critical Care Medicine, Seventh Medical Center, Chinese PLA General Hospital, Beijing 100700, China | changde@301hospital.com.cn |
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| Abstract:: |
| In the field of radiotherapy, radiation-induced bystander and abscopal effects have attracted increasing attention. Studies indicate that these effects can extend from irradiated regions to non-irradiated cells or tissues. Radiation-induced bystander and abscopal effects related to lung can be categorized into lung-lung type, lung-extrapulmonary tissue type, and extrapulmonary tissue-lung type. The mechanism of its occurrence involves oxidative stress, immune response, and the role of extracellular vesicles. These effects exhibit a dual characteristic of inducing damage to normal tissues and increasing tumor therapeutic potential. Immune responses represent a pivotal mechanism, and the combination of radiotherapy with immunotherapy may enhance the incidence of abscopal effects. Researchers are exploring various intervention strategies to control or utilize these effects. Future studies should further investigate the underlying biological mechanisms, particularly in specific organs or sites, to improve the efficacy and safety of radiotherapy. This review explores the latest advances in lung-related radiation-induced bystander and abscopal effects, encompassing their definitions, classifications, mechanisms, functional characteristics, influencing factors, and intervention strategies. |
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