| Wang Wenfei,Tian Chuan,Li Xueda,et al.Establishing an isodose assignment model for 125I brachytherapy using γ-ray photon counts detected by SPECT/CT[J].Chinese Journal of Radiological Medicine and Protection,2025,45(7):674-678 |
| Establishing an isodose assignment model for 125I brachytherapy using γ-ray photon counts detected by SPECT/CT |
| Received:July 30, 2024 |
| DOI：10.3760/cma.j.cn112271-20240730-00290 |
| KeyWords:SPECT/CT γ-ray photon count Dose 125I Brachytherapy |
| FundProject:国家重点研发计划项目(2019YFE0120100) |
| Author Name | Affiliation | E-mail | | Wang Wenfei | Department of Interventional Medical Center, Affiliated Hospital of Qingdao University, Qingdao 266003, China
Department of Radiology, Shengli Oilfield Central Hospital, Dongying 257099, China | | | Tian Chuan | Department of Interventional Medical Center, Affiliated Hospital of Qingdao University, Qingdao 266003, China | | | Li Xueda | Department of Interventional Medical Center, Affiliated Hospital of Qingdao University, Qingdao 266003, China | | | Zhang Hongtao | Department of Oncologyy, People's Hospital of Hebei Province, Shijiazhuang 050051, China | | | Wang Congxiao | Department of Interventional Medical Center, Affiliated Hospital of Qingdao University, Qingdao 266003, China | | | Liu Shifeng | Department of Interventional Medical Center, Affiliated Hospital of Qingdao University, Qingdao 266003, China | | | Hu Xiaokun | Department of Interventional Medical Center, Affiliated Hospital of Qingdao University, Qingdao 266003, China | huxiaokun770@163.com | | Li Teng | School of Artificial Intelligence, Anhui University, Hefei 230601, China | |
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| Abstract:: |
| Objective To employ single-photon emission computed tomography (SPECT)/CT for isodose assignment in 125I brachytherapy, assess the correlation between photon counts and dose values, and develop a clinical γ-ray visualization model for 125I brachytherapy. Methods 125I radioactive seeds were filled into a self-made 3D printed stereotactic template to build a stereotactic model. The model was scanned by SPECT/CT for photon counts at 0.5, 1.0, 1.5, 2.0 cm from the outermost peripheral seeds, and the corresponding dose values were measured using the Treatment Planning System (TPS). The fitting curve for the photon counts and the dose values was plotted using SPSS 27.0 software. Results The photon counts of γ rays at distances of 0.5, 1.0, 1.5, and 2.0 cm from the peripheral particles were 7 603.57±1 806.35, 4 018.26±1 315.72, 2 074.04±791.53, and 1 080.34±424.79, respectively, showing a significant difference (F=743.72, P<0.01). The dose values (in Gy) in the TPS at distances of 0.5, 1.0, 1.5, and 2.0 cm from the peripheral particles were 208.05±37.57, 125.43±17.74, 86.76±17.67, and 61.55±14.39, respectively, which were significantly different (F=930.46, P<0.01). The photon counts were linearly correlated with the dose values (y=0.02x+46.45, R2=81.2%, P<0.01). Conclusions SPECT/CT-based γ-ray photon count detection can be used to assign doses for 125I brachytherapy, enabling the visualization of γ rays in 125I brachytherapy. This approach has a distinct advantage over TPS, laying the foundation for the establishment of an alternative system to TPS. |
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