| Zhao Mengdie,Yi Junxuan,Jin Shunzi,et al.Advances in research on the role of tRNA-derived fragments in tumor formation and progression and their applications to radiotherapy for tumors[J].Chinese Journal of Radiological Medicine and Protection,2025,45(4):380-384 |
| Advances in research on the role of tRNA-derived fragments in tumor formation and progression and their applications to radiotherapy for tumors |
| Received:May 12, 2024 |
| DOI：10.3760/cma.j.cn112271-20240512-00172 |
| KeyWords:tRF Tumor Radiotherapy Tumor marker |
| FundProject:国家自然科学基金(82173454,81201737);吉林省科技发展计划资助项目(20200201524JC);吉林省教育厅科学研究项目(JJKH20211196KJ);吉林省财政厅卫生科研人才专项项目(2024SCZ66);吉林大学技术开发(委托)项目(2023220103000073);吉林大学中日联谊医院"研究者发起的临床研究项目-引导专项"(YJZ2024014) |
| Author Name | Affiliation | E-mail | | Zhao Mengdie | National Health Commission (NHC) Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun 130021, China | | | Yi Junxuan | National Health Commission (NHC) Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun 130021, China | | | Jin Shunzi | National Health Commission (NHC) Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun 130021, China | | | Wu Ning | National Health Commission (NHC) Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun 130021, China
Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun 130033, China | wuning@jlu.edu.c |
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| Abstract:: |
| tRNA-derived small RNAs (tsRNAs)—small RNA fragments derived from transfer ribonucleic acid (tRNA)—fall into the category of small non-coding RNAs (sncRNAs). They can be categorized into two major types: tRNA-derived fragments (tRFs) and tRNA-derived stress-induced small RNAs (tiRNAs). With the rapid advancement in high-throughput sequencing technologies and bioinformatics, tsRNAs have been involved in a variety of biological processes, including gene expression, signal transduction, and epigenetic inheritance, while also playing a significant role in tumor progression. The efficacy of radiotherapy is primarily affected by radiation-induced damage to normal tissues and the resistance of tumor cells to radiotherapy. It has been found that tsRNAs plays a significant role in radiation-induced cellular damage, as well as the modulation of radiation sensitivity and resistance. This highlights their potential as promising therapeutic targets in radiotherapy for tumors. This study reviews the origins, classification, biological functions of tRFs, as well as the advances in research on their role in tumor formation and progression and their applications in radiotherapy for tumors. This study aims to explore the research value of tRFs and their potential for application in radiotherapy for tumors. |
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