| Zhang Jia,Ruan Jianlei,Li Xiaoliang,et al.Analysis of circRNAs expression in peripheral blood of residents around radon hot springs[J].Chinese Journal of Radiological Medicine and Protection,2025,45(3):178-182 |
| Analysis of circRNAs expression in peripheral blood of residents around radon hot springs |
| Received:June 28, 2024 |
| DOI：10.3760/cma.j.cn112271-20240628-00244 |
| KeyWords:Radon hot spring Peripheral blood circRNAs Cumulative doses |
| FundProject: |
| Author Name | Affiliation | E-mail | | Zhang Jia | Key Laboratary of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Ruan Jianlei | Key Laboratary of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Li Xiaoliang | Key Laboratary of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Liu Jianxiang | Key Laboratary of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | liujianxiang@nirp.chinacdc.cn |
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| Abstract:: |
| Objective To investigate the effect of circular RNAs (circRNAs) expressions in peripheral blood of residents around radon hot springs. Methods Totally 51 residents around radon hot springs were selected as the radon hot sping group, and another 51 residents around non-radon hot springs were selected as the control group. Questionnaires were used to collect demographic information and the radon exposure levels in the two groups. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the relative expressions of selected circRNA candidates in peripheral blood of the two groups. Mann-Whitney U test was used to compare the differences in the relative expressions of the circRNAs between the two groups. Results The cumulative doses of radon exposure per capita for residents around radon hot springs was (111.47±99.03) mSv, with dose range 3.32-458.68 mSv. The difference in the relative expressions of hsa_circ_0040573 between the two groups was statistically significant (Z= -2.88, P< 0.05). The expression of hsa_circ_0040573 was suppressed by radon exposure (t= -2.52, P< 0.05) with a dose-dependent manner (H= 12.21, P< 0.05). Conclusion Hsa_circ_0040573 has a potential to serve as a radiological response biomarker for radon exposure, contributing to early diagnosis and monitoring of health risks associated with radon exposure. |
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