| Liu Jinghua,Cao Zhifei,Zhang Yongsheng.Research advances in the mechanisms of radiotherapy resistance in renal cell carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2024,44(10):886-890 |
| Research advances in the mechanisms of radiotherapy resistance in renal cell carcinoma |
| Received:May 17, 2024 |
| DOI：10.3760/cma.j.cn112271-20240517-00184 |
| KeyWords:Renal cell carcinoma (RCC) Radiotherapy resistance Radiotherapy Radiosensitizer |
| FundProject:国家自然科学基金(12275192);秦惠莙与李政道中国大学生见习进修基金;学科建设托举工程项目(XKTJ-XK202410) |
| Author Name | Affiliation | E-mail | | Liu Jinghua | Department of Pathology, Second Affiliated Hospital of Soochow University, Suzhou 215004, China
Department of Clinical Medicine, Suzhou Medical College, Soochow University, Suzhou 215123, China | | | Cao Zhifei | Department of Pathology, Second Affiliated Hospital of Soochow University, Suzhou 215004, China | | | Zhang Yongsheng | Department of Pathology, Second Affiliated Hospital of Soochow University, Suzhou 215004, China | shengyongzh@126.com |
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| Abstract:: |
| Radiotherapy serves as an effective means in the clinical treatment of renal cell carcinoma (RCC). Radiation resistance, denoting the decreased sensitivity of cancer cells to ionizing radiation during radiotherapy, is a common problem in tumor radiotherapy that is closely associated with the occurrence of adverse outcomes like tumor metastasis and recurrence. Focusing on RCC's radiotherapy resistance, this study elucidated the radiation resistance mechanisms of RCC cells in terms of DNA damage repair, cell cycle arrest, activation of the anti-apoptotic pathway, autophagy, and cancer stem cells. Moreover, it summarized the radiosensitizers currently used in RCC radiotherapy. This study aims to provide a novel approach for the mechanism study of RCC radiotherapy resistance, the improvement of radiotherapy strategies, and the innovative research and development of drugs. |
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