| Wei Xindi,Wang Jin,Chen Wei,et al.Cohort analysis of tumor effect for medical diagnostic X-ray workers in Jiangsu province[J].Chinese Journal of Radiological Medicine and Protection,2024,44(10):841-848 |
| Cohort analysis of tumor effect for medical diagnostic X-ray workers in Jiangsu province |
| Received:April 25, 2024 |
| DOI：10.3760/cma.j.cn112271-20240425-00156 |
| KeyWords:Medical diagnostic X-ray workers Tumor Radiation carcinogenesis |
| FundProject:中国医学科学院医学与健康科技创新工程(2021-I2M-1-042);江苏省医学重点学科(JSZJ20232201) |
| Author Name | Affiliation | E-mail | | Wei Xindi | School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Wang Jin | School of Public Health, Nanjing Medical University, Nanjing 211166, China
Department of Radiation Protection, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China | | | Chen Wei | Department of Radiation Protection, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China | chenw@jscdc.cn | | Zhang Zihao | School of Public Health, Nanjing Medical University, Nanjing 211166, China | | | Miao Yuji | Department of Radiation Protection, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China | | | Zhou Yuanyuan | Department of Radiation Protection, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China | | | Fan Xiangyong | Department of Radiation Protection, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China | | | Wang Jinhan | Department of Radiobiology, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China | | | Gu Yeqing | Department of Radiobiology, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China | |
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| Abstract:: |
| Objective To investigate the effects of long-term X-ray radiation exposure on the tumor risk of medical X-ray workers in Jiangsu province, and to provide a scientific basis for the development of occupational protection policies and the improvement of workers' health. Methods By using a combination of retrospective and prospective cohort research method, the medical diagnostic X-ray workers who worked in the radiology department of all hospitals in Jiangsu province between 1950 and 1980 were selected as the radiology group.In the meantime medical personnel in internal medicine, otorhinolaryngology, pediatrics and other medical departments who had not been engaged in radiology during the same period of time at the same hospital were selected as the control group to form a survey cohort. The cumulative number of person-years of observation of the cohort during 1950-2011 was calculated, and the relative risk of various malignant tumors among medical X-ray workers was calculated by using Cox regression model after adjusting for sex, attained age, year of birth, and year of work initiation. Results A total of 6 954 follow-ups was completed for the cohort, including 3 649 in the irradiation group and 3 305 in the control group, totally 340 483 person-years of observation. As of December 31,2021, there were 1 328 patients with malignant tumors in this cohort. Cox regression result showed that compared with the control group, the irradiation group who had developed lung cancer (RR=1.60, 95% CI 1.24-2.08), lymphoma (RR =4.28, 95% CI 1.54-11.93), solid cancer (RR =1.17, 95% CI 1.04-1.31), and total cancer (RR =1.29, 95% CI 1.14-1.46) had significantly higher relative risks (Z=3.56,2.78,2.71,3.96,P<0.05). Stratified analyses showed that the risks of lung, lymphoma, solid and total cancers were higher in the radiation group than in the control group for males and for those who arrived at the age of 61 years or older (χ2=6.70-33.86,P<0.05). The risks of lung, solid and total cancers were higher in the radiation group than in the control group for those who started to work in the age group of 21 to 25 years (χ2=6.46,6.16,5.62,P<0.05). Conclusions The relative risks of lung, lymphoma, solid and total cancers among medical X-ray workers in Jiangsu province are significantly higher, suggesting that attention should be paid to strengthening radiation protection for radiation workers in their radiological practices. |
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