| Chen Liang,Liang Yiyin,Zhang Weiwei,et al.Advances in application of organoids to research on radiotherapy of tumors[J].Chinese Journal of Radiological Medicine and Protection,2024,44(6):543-548 |
| Advances in application of organoids to research on radiotherapy of tumors |
| Received:November 03, 2023 |
| DOI：10.3760/cma.j.cn112271-20231103-00158 |
| KeyWords:Organoids Radiotherapy Experimental model Personalized therapy Radiotherapy sensitization |
| FundProject:上海卫生健康委员会领军人才计划(2022LJ019); 国家自然科学基金面上项目(82272742); 科技部国家重点研发计划(2022YFC2503701, FW-ZXKT2022102502004); 长海医院"固海"计划(GH145-33). |
| Author Name | Affiliation | E-mail | | Chen Liang | Department of Radiotherapy, Changhai Hospital, Naval Medical University, Shanghai 200433, China | | | Liang Yiyin | Department of Radiotherapy, Changhai Hospital, Naval Medical University, Shanghai 200433, China | | | Zhang Weiwei | Department of Radiotherapy, Changhai Hospital, Naval Medical University, Shanghai 200433, China | | | Tong Jiaojiao | Department of Radiotherapy, Changhai Hospital, Naval Medical University, Shanghai 200433, China | | | Zhang Huojun | Department of Radiotherapy, Changhai Hospital, Naval Medical University, Shanghai 200433, China | chyyzhj@163.com |
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| Abstract:: |
| Organoids are in vitro-cultured three-dimensional (3D) miniature structures derived from human pluripotent stem cells or adult stem cells from healthy individuals or patients. Compared to traditional two-dimensional (2D) cell lines or animal models, organoids are regarded as more promising high-fidelity models, possessing unique advantages in terms of disease modeling, drug development, the establishment of living biobanks, and the exploration of personalized treatment. Over recent years, the rapid development of organoid technology has brought new hopes for innovating preclinical experimental tumor models and promoting clinical personalized diagnosis and treatment. This review is intended to introduce the development status and latest progress of organoids in the field of radiotherapy for tumors, explore the advantages and limitations of organoid models for cancer, and prospect for its application in the field of radiotherapy. |
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