Shi Yabin,Chen Weisi,Xu Yi,et al.Dosimetric analysis of dynamic intensity modulated radiotherapy with active breathing coordinator and Catalyst for respiratory gating after breast conserving surgery for left breast cancer[J].Chinese Journal of Radiological Medicine and Protection,2024,44(5):415-420
Dosimetric analysis of dynamic intensity modulated radiotherapy with active breathing coordinator and Catalyst for respiratory gating after breast conserving surgery for left breast cancer
Received:July 21, 2023  
DOI:10.3760/cma.j.cn112271-20230721-00013
KeyWords:Deep inspiration breath hold  Respiratory gating  Intensity modulated radiotherapy  Breast conserving surgery
FundProject:海南省卫生计生行业科研项目(19A200096)
Author NameAffiliationE-mail
Shi Yabin Department of Radiation Oncology, Shenzhen People's Hospital, Second Clinical Medical College, Jinan University, First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, China  
Chen Weisi Department of Radiation Oncology, Shenzhen People's Hospital, Second Clinical Medical College, Jinan University, First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, China
Department of Radiation Oncology, First Affiliated Hospital of Hainan Medical University, Haikou 570102, China 
 
Xu Yi Second Department of Infectious Disease, Shenzhen Third People's Hospital, Shenzhen 518112, China  
Li Longxing Department of Radiation Oncology, Shenzhen People's Hospital, Second Clinical Medical College, Jinan University, First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, China  
Chen Hongtao Department of Radiation Oncology, Shenzhen People's Hospital, Second Clinical Medical College, Jinan University, First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, China  
Li Zihuang Department of Radiation Oncology, Shenzhen People's Hospital, Second Clinical Medical College, Jinan University, First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, China li.zihuang@szhospital.com 
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Abstract::
      Objective To compare the dosimetric differences between active breathing coordinator (ABC) and Catalyst for respiratory gating after breast conserving surgery for left breast cancer. Methods Data of 48 female patients with left breast cancer after breast conserving surgery admitted to the Radiotherapy Department of Shenzhen People's Hospital from November 2020 to August 2021 were retrospectively selected. They were randomized to receive dynamic intensity modulated radiotherapy (IMRT) plans with ABC or Catalyst. The dosimetric differences in targets and organs at risk between the two groups were analyzed. Results Comparison of the two respiratory gating IMRT plans revealed no statistically significant differences (P > 0.05) in D90%, D98%, Dmax, Dmean, conformity index (CI), homogeneity index (HI), and monitor unit parameters in the target volume, (i.e., chest wall), as well as the ipsilateral lung and heart under the deep inhalation breath hold (DIBH) mode. The Dmean, Dmax, and D2% of the left anterior descending coronary artery (LAD) in the Catalyst group were better than those in the ABC group [(1047.72 ± 1401.84) vs. (454.48 ± 206.26), (1619.28 ± 809.05) vs.(1068.53 ± 419.63), (1405.85 ± 798.30) vs. (1016.54 ± 592.00) cGy], with statistically significant differences (t= -2.07, -3.18, -2.07, P<0.05). Conclusions Both ABC and Catalyst respiratory gating systems meet the requirements for clinical treatment, with the latter more effective in reducing the exposure dose of LAD.
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