| He Yuanfang,Liu Ruixue,Yan Haili,Du Jiangfeng.Applications of key molecules targeting DNA damage response in tumor radiosensitization[J].Chinese Journal of Radiological Medicine and Protection,2024,44(4):323-329 |
| Applications of key molecules targeting DNA damage response in tumor radiosensitization |
| Received:August 02, 2023 |
| DOI：10.3760/cma.j.cn112271-20230802-00028 |
| KeyWords:Radiotherapy DNA damage repair Targeting Radiosensitization Immune response |
| FundProject:国家自然科学基金(81901889);山西省“四个一批”科技兴医创新计划重点项目(2023XM036) |
| Author Name | Affiliation | E-mail | | He Yuanfang | College of Pharmacy, Shanxi Medical University, Jinzhong 030619, China | | | Liu Ruixue | Department of Medical Imaging, First Hospital of Shanxi Medical University, Taiyuan 030001, China | | | Yan Haili | Department of Medical Imaging, First Hospital of Shanxi Medical University, Taiyuan 030001, China | | | Du Jiangfeng | Department of Medical Imaging, First Hospital of Shanxi Medical University, Taiyuan 030001, China | dujf@sxmu.edu.cn |
|
| Hits: 220 |
| Download times: 72 |
| Abstract:: |
| Radiotherapy, an important method for clinically treating tumors, causes serious damage to tumor cells primarily by destroying DNA double strands. However, the outcomes of radiotherapy alone are limited by tumor cells' inherent capacity for DNA damage repair. Multiple studies have shown that key molecules targeting DNA damage response (DDR) can effectively inhibit DNA damage repair while synergistically enhancing radiotherapy and chemotherapy sensitivity. This study reviews the applications of some key DDR inhibitors combined with radiotherapy or chemotherapy in the treatment of various tumors, elaborates on cyclin guanine nucleotide adenine nucleotide synthase-interferon gene stimulator (cGAS-STING)-mediated immune responses induced by combination therapy, and finally summarizes and predicts the challenges and development prospects of combination therapy. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
