| Wu Weiqing,Yuan Xianglin,Hu Guangyuan,Zheng Renchao,Li Qianxia,Liu Fei,Lu Xiaoguang.Application of adaptive aperture in proton radiotherapy for brain tumors[J].Chinese Journal of Radiological Medicine and Protection,2024,44(1):24-28 |
| Application of adaptive aperture in proton radiotherapy for brain tumors |
| Received:May 30, 2023 |
| DOI：10.3760/cma.j.cn112271-20230530-00166 |
| KeyWords:Brain tumor Adaptive aperture Proton Radiotherapy |
| FundProject:2023湖北省科技计划项目(2023BCB096) |
| Author Name | Affiliation | E-mail | | Wu Weiqing | Department of Oncology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | | Yuan Xianglin | Department of Oncology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | | Hu Guangyuan | Department of Oncology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | | Zheng Renchao | Department of Oncology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | | Li Qianxia | Department of Oncology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | | Liu Fei | Department of Oncology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | | Lu Xiaoguang | Department of Oncology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | luxiaoguang@tjh.tjmu.edu.cn |
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| Abstract:: |
| Objective To evaluate the clinical application value of the adaptive aperture by comparing intensity-modulated proton radiotherapy(IMPT) plans using and not using the aperture for brain tumors. Methods A total of twenty patients treated with postoperative radiotherapy for brain tumors were enrolled in this study. IMPT plans were developed for each patient using and not using the adaptive aperture under the same optimization conditions. The target conformal index (CI) value, target homogeneity index (HI) value, and the dose to normal tissues of the two sets of plans were compared. Results The IMPT plans designed using the adaptive aperture significantly increased the mean CI value from 0.58 to 0.66, while decreasing the mean 50% prescription dose volume from 797.70 cm3 to 638.15 cm3. These plans also reduced the irradiation doses to the cochlea, brainstem, optic chiasm, optic nerve, and lens (t = 2.06, 3.02, 2.11, 2.58, 2.67, P < 0.05). Additionally, there was no significant difference in the HI value of the target volumes and the machine jumps (MU) between the two sets of plans (P > 0.05). Conclusions The adaptive aperture can significantly reduce the irradiation dose to normal tissues outside the target volumes, positively impacting the protection of organs at risk (OARs) around the target values. This demonstrates its great potential for clinical application. |
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