| Li Weiguo,Gao Gang,Pan Yan,Ruan Jianlei,Liu Jianxiang.A review of regulatory effects of radiation on the polarization and functions of macrophages[J].Chinese Journal of Radiological Medicine and Protection,2023,43(10):839-844 |
| A review of regulatory effects of radiation on the polarization and functions of macrophages |
| Received:February 07, 2023 |
| DOI：10.3760/cma.j.cn112271-20230207-00028 |
| KeyWords:Macrophage Polarization Radiation Signaling pathway |
| FundProject: |
| Author Name | Affiliation | E-mail | | Li Weiguo | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Protection, Beijing 100088, China | | | Gao Gang | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Protection, Beijing 100088, China | | | Pan Yan | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Protection, Beijing 100088, China | | | Ruan Jianlei | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Protection, Beijing 100088, China | | | Liu Jianxiang | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Protection, Beijing 100088, China | liujianxiang@nirp.chinacdc.cn |
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| Abstract:: |
| Macrophages, as regulatory cells existing in all tissues, exhibit complex responses to radiation stimulation, including both common processes in response to infection and injury and unique polarization transformation. Radiation-related polarization determines the functional types of macrophages. After being exposed to different irradiations, macrophages are regulated by different cytokines, involving multiple signaling pathways. This leads to differential degrees of polarization. The review summarized the regulatory effects of radiation on the polarization and functions of macrophages in order to provide basis for theoretical research on immunity and clinical radiotherapy. |
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