| Liu Jia,Jiao Yang,He Min,Cai Yiling,Guo Hongjuan,Yin Huafang,Wang Jian.Low-dose radiation therapy for severe/critical COVID-19: benefits or risks?[J].Chinese Journal of Radiological Medicine and Protection,2023,43(9):747-751 |
| Low-dose radiation therapy for severe/critical COVID-19: benefits or risks? |
| Received:February 20, 2023 |
| DOI：10.3760/cma.j.cn112271-20230220-00042 |
| KeyWords:COVID-19 Low-dose radiation therapy Pneumonia |
| FundProject:江苏省卫生健康委员会重点科研项目（ZD2021053）；放射医学与辐射防护国家重点实验室科研创新项目（GZC00402）；江阴市科技局社会发展科技示范项目（JY0603A021014210005PB）；无锡市"双百"医疗人才计划项目（202014） |
| Author Name | Affiliation | E-mail | | Liu Jia | Tumor Center, Jiangyin Hospital Affiliated to Nantong University, Jiangyin 214400, China | | | Jiao Yang | State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China | | | He Min | Tumor Center, Jiangyin Hospital Affiliated to Nantong University, Jiangyin 214400, China | | | Cai Yiling | Tumor Center, Jiangyin Hospital Affiliated to Nantong University, Jiangyin 214400, China | | | Guo Hongjuan | State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China | | | Yin Huafang | Tumor Center, Jiangyin Hospital Affiliated to Nantong University, Jiangyin 214400, China | | | Wang Jian | Tumor Center, Jiangyin Hospital Affiliated to Nantong University, Jiangyin 214400, China | 1627879372@qq.com |
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| Abstract:: |
| Patients with severe or critical coronavirus disease 2019 (COVID-19) are at high risk of death primarily due to respiratory failure caused by the cytokine storm in pulmonary tissues. The treatment response of these patients remains limited. Recently, low-dose radiation therapy (LDRT) has been clinically adopted to treat severe or critical COVID-19 patients in multiple medical centers abroad, indicating high feasibility and effectiveness. However, the mechanism and optimal radiation dose are still incompletely clear. This paper reviews the radiobiological mechanism, effectiveness, adverse reactions, and radiotherapy dose of LDRT in the treatment of severe or critical COVID-19 patients, aiming to better understand the clinical benefits and adverse reactions of LDRT. |
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