| Feng Yang,Cao Jianping,Jiao Yang.The key role of RNA N6-methyladenosine (m6A) methylation in tumor radiotherapy and radiation damage repair[J].Chinese Journal of Radiological Medicine and Protection,2023,43(7):559-563 |
| The key role of RNA N6-methyladenosine (m6A) methylation in tumor radiotherapy and radiation damage repair |
| Received:December 06, 2022 |
| DOI：10.3760/cma.j.cn112271-20221206-00471 |
| KeyWords:N6-methyladenosine modification(m6A)|m6A methyltransferase (Writers)|m6A demethylase (Erasers)|m6A methylation recognition enzymes (Readers)|Radiation-induced injuries |
| FundProject:国家自然科学基金(U1967220,81773226);国家重点研发计划项目(2022YFC2503700,2022YFC2503703) |
| Author Name | Affiliation | E-mail | | Feng Yang | School of Radiation Medicine and Protection, State Key Laboratory of Radiation Medicine and Radiation Protection, Soochow University, Co-Innovation Center for Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China | | | Cao Jianping | School of Radiation Medicine and Protection, State Key Laboratory of Radiation Medicine and Radiation Protection, Soochow University, Co-Innovation Center for Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China | | | Jiao Yang | School of Radiation Medicine and Protection, State Key Laboratory of Radiation Medicine and Radiation Protection, Soochow University, Co-Innovation Center for Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China | jiaoyang@suda.edu.cn |
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| Abstract:: |
| N6-methyladenosine (m6A) is the most abundant epigenetic modification in eukaryotic messenger RNA (mRNA), which could be catalyzed by m6A methyltransferase (Writers), recognized by methylation recognition enzymes (Readers), and removed by demethylase (Erasers). RNA splicing, translation, and stability could be modulated by m6A methylation modification. The m6A methylation modification is involved in the biological regulation of a variety of important functional genes in cellular activities. Importantly, abnormal m6A modification affects the occurrence, development, metastasis and recurrence of tumors. Ionizing radiation can affect the level of m6A and m6A methylation-related enzymes. Recently, m6A methylation is reported to regulate the efficacy of tumor radiotherapy by affecting DNA damage and radiosensitivity of tumor cells. In addition, ionizing radiation can also affect the level of m6A modification in normal cells to regulate the progress of radiation-induced injuries. This review summarizes the research progress on the roles of m6A methylation in tumor radiosensitivity and radiation-induced injuries, with the aim of providing novel strategies for the development of clinical tumor radiosensitizers and radioprotective agents. |
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