| Yang Yong,Wang Qiang,Yang Luting,Yu Aiqing,Zhao Zhixin,Zhu Bo,Jing Liyan.Meta-analysis of the effects of low-dose ionizing radiation on the thyroid of medical radiation workers[J].Chinese Journal of Radiological Medicine and Protection,2023,43(6):447-456 |
| Meta-analysis of the effects of low-dose ionizing radiation on the thyroid of medical radiation workers |
| Received:February 08, 2023 |
| DOI：10.3760/cma.j.cn112271-20230208-00030 |
| KeyWords:Radiation worker Ionizing radiation Thyroid Meta analysis |
| FundProject:杭州市科技计划引导项目（20191231Y055）；杭州市医药卫生科技项目（A20200566）；浙江省医药卫生科技计划项目（2022KY1043） |
| Author Name | Affiliation | E-mail | | Yang Yong | Hangzhou Hospital for Prevention and Treatment of Occupational Diseases, Hangzhou 310014, China | | | Wang Qiang | Hangzhou Hospital for Prevention and Treatment of Occupational Diseases, Hangzhou 310014, China | hz1618@126.com | | Yang Luting | Hangzhou Hospital for Prevention and Treatment of Occupational Diseases, Hangzhou 310014, China | | | Yu Aiqing | Hangzhou Hospital for Prevention and Treatment of Occupational Diseases, Hangzhou 310014, China | | | Zhao Zhixin | Hangzhou Hospital for Prevention and Treatment of Occupational Diseases, Hangzhou 310014, China | | | Zhu Bo | Hangzhou Hospital for Prevention and Treatment of Occupational Diseases, Hangzhou 310014, China | | | Jing Liyan | Hangzhou Hospital for Prevention and Treatment of Occupational Diseases, Hangzhou 310014, China | |
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| Abstract:: |
| Objective To assess the effects of low-dose ionizing radiation on the thyroid of medical radiation workers.Methods Based on the inclusion and exclusion criteria, 27 articles, involving 22 937 individuals, were screened finally from relevant literature published from 1996 to 2022. Meta-analysis was carried out using Stata 16.0 for serum levels of triiodothyronine (T3), free triiodothyronine (FT3), thyroid hormone (T4), free thyroid hormone (FT4), thyrotropin-stimulating hormone (TSH) and thyroid nodule rates. As well, subgroup analysis were carried out of thyroid function in different types of radiation workers.Results The standardized mean difference (SMD) at T3 and T4 levels for radiation workers was -0.19 (-0.37,-0.01) and -0.34 (-0.38, -0.30), lower than that of control group (Z=2.07,-16.06,P<0.05). The SMD at FT4 levels for radiation workers was 0.22 (0.06, 0.39), higher than control group (Z=2.61, P<0.05). The relative risk of thyroid nodules in radiation workers was 1.47 (1.19,1.82), higher than that of control group (Z=-3.58, P<0.05). The analysis result for subgroup showed that the SMD for T3, T4 and TSH levels in the interventional radiology workers were -0.29 (-0.51, -0.07), -0.31 (-0.47, -0.15) and -0.43 (-0.73, -0.13) (Z=-2.55, -3.86, -2.82, P<0.05), respectively, and the SMD for T4 levels in the nuclear medicine workers was -0.26 (-0.45, -0.07), which meaned a reduced risk compared to the control group (Z=-2.70, P<0.05).Conclusions Long-term low doses of ionising radiation may have adverse effects on thyroid hormone and thyroid nodule in radiation workers, particularly in interventional radiology workers, and attention should be focused on their radiation protection. |
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